Value of Immunohistochemistry to Differentiate Digital Papillary Adenocarcinoma From Acral Hidradenoma With Papillary Structures.

Abstract

ABSTRACT:

Digital papillary adenocarcinoma is a malignant adnexal tumor with a predilection for acral sites. Hidradenoma is a benign solid and cystic sweat gland neoplasm with focal ductal and glandular differentiation and good outcomes. Hidradenomas can occur at acral sites and show papillary structures; for this reason, they are included in the differential diagnosis of digital papillary adenocarcinoma, and immunohistochemistry is a valuable tool in this scenario. We described a case of a 43-year-old man with an epithelial tumor showing papillary structures in the intermediate phalanx of the fourth finger. There was diffuse positivity for p63 and negativity for S100 protein, suggesting that this tumor was an acral hidradenoma with papillary structures.

• Authors: José Cândido Caldeira Xavier-Júnior, Deolino João Camilo-Júnior, André Luiz Carneiro Dias, Pedro Paulo Marques Ferreira, Antonio Roberto Abdalla Filho, Thomas Brenn
• Journal: The American Journal of dermatopathology (Am J Dermatopathol) Vol. 44 Issue 11 Pg. 843-845 (Nov 01 2022) ISSN: 1533-0311 [Electronic] United States
• PMID: 36066118 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• S100 Proteins

Topics

• Acrospiroma (diagnosis, surgery)
• Adenocarcinoma, Clear Cell
• Adenocarcinoma, Papillary (chemistry, diagnosis, surgery)
• Adenoma, Sweat Gland (pathology)
• Adult
• Bone Neoplasms
• Breast Neoplasms
• Carcinoma, Skin Appendage
• Humans
• Immunohistochemistry
• Male
• S100 Proteins
• Skin Neoplasms (diagnosis, pathology, surgery)
• Sweat Gland Neoplasms (diagnosis, metabolism, surgery)