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S100 Proteins (S 100 Protein)

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A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.

Also Known As:

S 100 Protein; Nerve Tissue Protein S 100; S-100 Protein; S100 Protein Family; Antigen S 100

Networked: 2198 relevant articles (26 outcomes, 241 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 72216
  - Carrier Proteins: 9338
    - Calcium-Binding Proteins: 230
      - S100 Proteins: 2198
        Leukocyte L1 Antigen Complex: 515
        S-100 calcium-binding protein beta subunit: 262
        S100A1 protein: 12
        S100 calcium binding protein A10: 2
        human S100A4 protein: 1
        Bos taurus S100A4 protein
        Gallus gallus calcyclin protein
        human calcitermin peptide
        human calcium-binding protein p6
        human S-100A8 N-terminal peptide
        human S100A11 protein
        human S100A12 protein
        human S100A13 protein
        human S100A2 protein
        human S100A3 protein
        human S100A5 protein
        human S100A6 protein
        human S100A7 protein
        human S100A7A protein
        human S100Z protein
        mouse RPTN protein
        mouse S100A11 protein
        mouse S100a13 protein
        mouse S100A15 protein
        mouse S100A2 protein
        mouse S100a3 protein
        mouse S100A4 protein
        mouse S100a6 protein
        mouse S100A7 protein
        mouse S100a8 protein
        Rana catesbeiana P26OLF protein
        rat S100A2 protein
        rat S100a4 protein
        rat S100a6 protein
        rat S100RVP protein
        S-100 calcium-binding protein alpha subunit
        Xenopus dicalcin protein
  - Nerve Tissue Proteins: 1
    - S100 Proteins: 2198

Experts

1.	Scheithauer, Bernd W: 7 articles (09/2012 - 04/2002)
2.	Michal, Michal: 6 articles (11/2012 - 06/2006)
3.	Hirose, Takanori: 6 articles (10/2012 - 04/2002)
4.	Heizmann, Claus W: 5 articles (01/2009 - 05/2002)
5.	Miettinen, Markku: 5 articles (06/2006 - 05/2003)
6.	Thompson, Lester D R: 4 articles (09/2012 - 05/2003)
7.	Suster, Saul: 4 articles (11/2011 - 04/2002)
8.	Hasegawa, Tadashi: 4 articles (11/2010 - 08/2003)
9.	Roth, Johannes: 4 articles (10/2009 - 06/2003)
10.	Lasota, Jerzy: 4 articles (06/2006 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2005 - "Immunoperoxidase staining S-100 protein and HMB 45 demonstrated immunoreactivity for both, confirming the diagnosis of MM. In conclusion, MMs are rare histologically benign tumors that can be cured by complete surgical resection alone, which should be the goal of the treatment. " 02/01/1987 - "Immunohistochemical identification of the S-100 protein represents an improvement in current histochemical differential diagnosis of these tumors." 01/01/2010 - "The present study has focussed on S100 proteins as a potentially promising group of markers in cancer development and progression. " 10/01/2008 - "Immunohistochemical study showed that the tumor cells expressed S-100 protein. " 12/01/2005 - "Previous studies suggest that some S100 proteins are involved in the progression of certain types of cancer. " Order ALL the reference details at left...
2.	Melanoma (Melanoma, Malignant) 10/01/1988 - "These results indicated that HMB-45 monoclonal antibody has a higher specificity for melanoma cells than did S-100 protein and that, because of its reactivity in routinely processed tissues, it may be helpful in surgical pathology." 01/01/1999 - "In this study we examined the concentration changes of serum S-100 protein and 5-S-CD in 252 melanoma patients of different clinical stages. " 09/01/1997 - "In the present study, the concentration of serum S-100 protein was measured in 97 patients with histologically proven malignant melanoma who were attending a dermatology and/or oncology department for the follow-up of their disease. " 07/01/1997 - "In the present study serum levels of S-100 protein beta were measured in 643 patients with cutaneous malignant melanoma. " 06/01/1997 - "In an attempt to illustrate a biological difference between the 2 melanomas, immunohistochemical studies were performed on sections of the 2 specimens using S-100 protein, HMB-45, and S-100-beta. " Order ALL the reference details at left...
3.	Carcinoma (Carcinomatosis) 03/01/2001 - "To study the relationship between S-100 protein and prognosis of laryngeal carcinoma. " 01/01/1987 - "An immunohistochemical study of S-100 protein in 43 nasopharyngeal carcinomas (NPC) of known clinical evolution (33 primary and 10 metastatic) is presented. " 01/01/2010 - "Using immunohistochemistry, the expressions of CK7, CK19, CK20, GCDFP-15, CEA, S-100 protein and bcl-2 were examined to elucidate the cellular differentiation of the carcinoma. " 03/01/2001 - "Our result indicated that the detection of S-100 protein is of value for the prognostic analysis in patients with laryngeal carcinoma." 03/01/2001 - "The result showed that S-100 protein positive were found 43 (63.24%) in 68 laryngeal carcinoma. " Order ALL the reference details at left...
4.	Sarcoma (Soft Tissue Sarcoma) 05/01/1991 - "Immunohistochemical studies demonstrated the presence of a neuroectodermal marker S-100 protein within some sarcoma cells. " 05/01/2011 - "Endothelial markers, S-100 protein, and CD117 do not seem to be of any diagnostic value in uterine sarcomas. " 01/01/2003 - "Whereas CD1a-positive dendritic cells were not detected, S-100 protein-positive or CD83-positive dendritic cells were observed in five sarcoma tissues. " 09/01/1988 - "Almost all the sarcoma cells in every tumour specimen harboured immunoreactivity to both alpha- and beta-subunits of S-100 protein. " 10/01/1997 - "Although the cytomorphologic features may strongly suggest MPNST, clinical correlation is necessary and immunocytochemistry (i.e., S-100 protein) may help to distinguish MPNST from other spindle-cell sarcomas. " Order ALL the reference details at left...
5.	Chordoma 11/15/1993 - "Forty-four percent of classic and 85% of chondroid chordomas were positive for S-100 protein. " 12/01/1992 - "In contrast, the remaining three cases without histologic evidence of chordoma differentiation did not stain for CK or EMA, but they did stain for S-100 protein (three of three cases) and VIM (three of three cases). " 05/01/1997 - "Immunocytochemistry with positivity for S-100 protein and cytokeratins was an essential adjunct in the cytologic diagnosis of chordoma and helped in distinguishing it from other chondrogenic tumors. " 12/01/1992 - "Similarly, the conventional chordoma components of these same 13 neoplasms stained for CK (12 of 12 cases), EMA (13 of 13 cases), VIM (12 of 12 cases), S-100 protein (nine of 12 cases), and CEA (two of nine cases). " 02/15/1988 - "Reticulum histiocytic cells of eosinophilic granulomas and chordoma cells were positive for S-100 protein. " Order ALL the reference details at left...

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5.	Mucin-1 (CA 15-3 Antigen)
6.	Glial Fibrillary Acidic Protein
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8.	Carcinoembryonic Antigen
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Related Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy)
2.	Lymph Node Excision (Lymph Node Dissection)
3.	Transplants (Transplant)
4.	Cardiopulmonary Resuscitation (CPR)
5.	Penetrating Keratoplasty

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