MGMT in glial carcinogenesis. Roles from prevention to treatment.
|
| Abstract |
Many investigations exist regarding the effect of the DNA repair enzyme MGMT (O 6 -methylguanine- DNA-methyltransferase)-encoding gene methylation on the antineoplasticity of temozolomide in glioblastoma patients. However, there exist surprisingly lesser studies regarding the associations between MGMT enzyme biochemistry with glial carcinogenesis. MGMT involves in risk of malignancies associated with ionizing radiation, smoking, exposure to polycyclic aromatic hydrocarbons, chlorinated solvents, vinylchloride and hairdyes. All these factors are also proposed to link with gliomagenesis, yet MGMT interactions with these carcinogens in gliomagenesis are not studied yet. In future, MGMT sequencing may be employed in vulnerable populations working in industries associated with exposure to these carcinogens to develop preventive strategies. Given that MGMT is involved in DNA repair, a polymorphism may simultaneously modify the risk of gliomas while enhancing temozolomide cytotoxicity in both marrow and tumor cells.
|
|---|---|
| Authors | İlhan Elmaci, Meric A Altinoz, Eylem Burcu Kahraman Ozlu, Ramazan Sari, Ozlem Er, Cumhur Gokhan Ekmekci, Burcu Turkgenc, Alp Ozpinar, Emily Hacker, Aysel Ozpinar |
| Journal | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 31 Issue 6 Pg. 568-576 (11 01 2022) ISSN: 1473-5709 [Electronic] England |
| PMID | 35671254 (Publication Type: Journal Article) |
| Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!