Abstract | AIMS: MATERIALS AND METHODS: As part of a larger study, this was a 16 week, double-blind, randomized, placebo-controlled trial. Subjects with obesity and type 2 diabetes were randomized (1:1:1:1) to dapagliflozin 10 mg with exenatide-matched placebo, exenatide twice-daily 10 μg with dapagliflozin-matched placebo, dapagliflozin plus exenatide, or double placebo. Using functional magnetic resonance imaging, the effects of treatments on brain responses to the anticipation of food and food receipt were assessed after 10 days and 16 weeks. RESULTS: After 10 days, dapagliflozin increased activation in right amygdala and right caudate nucleus in response to the anticipation of food, and tended to decrease activation in right amygdala in response to actual food receipt. After 16 weeks, no changes in brain activation were observed with dapagliflozin. Dapagliflozin plus exenatide reduced activation in right caudate nucleus and amygdala to the anticipation of food, and decreased activation in the right amygdala in response to food receipt after 16 weeks. CONCLUSIONS:
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Authors | Charlotte C van Ruiten, Dick J Veltman, Madelief Wijdeveld, Jennifer S Ten Kulve, Mark H H Kramer, Max Nieuwdorp, Richard G IJzerman |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 24
Issue 8
Pg. 1588-1597
(08 2022)
ISSN: 1463-1326 [Electronic] England |
PMID | 35491524
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. |
Chemical References |
- Benzhydryl Compounds
- Blood Glucose
- Glucosides
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Sodium-Glucose Transporter 2 Inhibitors
- dapagliflozin
- Sodium
- Exenatide
- Glucose
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Topics |
- Benzhydryl Compounds
(therapeutic use)
- Blood Glucose
- Brain
(metabolism)
- Diabetes Mellitus, Type 2
(drug therapy)
- Double-Blind Method
- Exenatide
(therapeutic use)
- Glucose
(therapeutic use)
- Glucosides
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemic Agents
- Obesity
(complications, drug therapy)
- Sodium
- Sodium-Glucose Transporter 2 Inhibitors
(therapeutic use)
- Weight Loss
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