mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron.
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| Abstract |
Knowledge about the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the elderly on mRNA vaccination response is needed to appropriately address the demand for additional vaccinations in this vulnerable population. Here, we show that octogenarians, a high-risk population, mount a sustained SARS-CoV-2 spike-specific immunoglobulin G (IgG) antibody response for 15 months following infection. This response boosts antibody levels 35-fold upon receiving a single dose of BNT162b2 mRNA vaccine 15 months after recovery from coronavirus disease 2019 (COVID-19). In contrast, antibody responses in naive individuals boost only 6-fold after a second vaccine. Spike-specific angiotensin-converting enzyme 2 (ACE2) antibody binding responses in the previously infected octogenarians following two vaccine doses exceed those found in a naive cohort after two doses. RNA sequencing (RNA-seq) demonstrates activation of interferon-induced genetic programs, which persist only in the previously infected. A preferential increase of specific immunoglobulin G heavy chain variable (IGHV) clonal transcripts that are the basis of neutralizing antibodies is observed only in the previously infected nuns.
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| Authors | Hye Kyung Lee, Ludwig Knabl, Juan I Moliva, Ludwig Knabl Sr, Anne P Werner, Seyhan Boyoglu-Barnum, Sebastian Kapferer, Birgit Pateter, Mary Walter, Nancy J Sullivan, Priscilla A Furth, Lothar Hennighausen |
| Journal | Cell reports (Cell Rep) Vol. 39 Issue 2 Pg. 110680 (04 12 2022) ISSN: 2211-1247 [Electronic] United States |
| PMID | 35395191 (Publication Type: Journal Article) |
| Copyright | Published by Elsevier Inc. |
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