Hepatocellular carcinoma (HCC) remains one of the most prevalent human
malignancies with high mortality. Increasing studies have revealed
microRNAs (
miRNAs) play crucial roles in the
tumorigenesis and progression of
cancers. The current study investigated the expression levels of
miR-1229-3p and its potential role in HCC. This study enrolled 121 HCC patients. The expression of
miR-1229-3p was measured using RT-qPCR in HCC tissue samples and cell lines. The association of
miR-1229-3p expression with clinical parameters and patients' prognosis was analyzed by χ2 test, Kaplan-Meier, and multivariate Cox regression analyses, respectively. The functions of
miR-1229-3p in HCC cells were explored by
CCK-8 assay, Transwell migration, and invasion assays.
miR-1229-3p was upregulated in HCC tissue samples and cell lines. The upregulation of
miR-1229-3p was related to positive
lymph node metastasis and advanced TNM stages and predicted with patients' poor prognosis. Overexpression of
miR-1229-3p facilitated cell viability and
metastasis of HCC cells while knockdown of
miR-1229-3p suppressed cell viability and
metastasis of HCC cells in vitro.
miR-1229-3p may function as an oncogenic role in HCC via promoting cell viability and
metastasis. Moreover,
miR-1229-3p may be a predictive marker for
tumor development and prognosis of HCC patients.