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Carboxymethyl-glucan from Saccharomyces cerevisiae reduces blood pressure and improves baroreflex sensitivity in spontaneously hypertensive rats.

Abstract
Carboxymethyl-glucan (CMG) is a derivative of β-D-glucan extracted from Sacharomyces cerevisae. This polymer presents improved physicochemical properties and shows health benefits, such as immunomodulation, antioxidant, anti-inflammatory, anti-tumor, and antiplatelet activities, and improved vascular function. However, studies concerning the effect of administration of CMG on the cardiovascular parameters, mainly in the field of hypertension, are scarce. This study aimed to investigate the effect of administration of CMG in spontaneously hypertensive rats (SHR) and normotensive rats (WKY) models. Normotensive and hypertensive animals received CMG at doses of 20 mg kg-1 and 60 mg kg-1 for four weeks. Then, weight gain, lipid profile, renal function, blood pressure, cardiac hypertrophy, baroreflex sensitivity, and sympathetic tone were evaluated. Oral administration of CMG influenced weight gain and cholesterol levels, and significantly reduced urea in the hypertensive animals. It decreased blood pressure levels and cardiac hypertrophy, improved baroreflex response, and reduced the influence of sympathetic tone. The results demonstrate the antihypertensive effect of CMG through improvement in baroreflex sensitivity via sympathetic tone modulation.
AuthorsLorena Soares Bezerra, Marciane Magnani, Tatiana Colombo Pimentel, Francisca Manuela de Souza Freire, Tays Amanda Felisberto da Silva, Ricardo Cartaxo Ramalho, Adriano Francisco Alves, José Luiz de Brito Alves, Isac Almeida de Medeiros, Robson Cavalcante Veras
JournalFood & function (Food Funct) Vol. 12 Issue 18 Pg. 8552-8560 (Sep 20 2021) ISSN: 2042-650X [Electronic] England
PMID34337642 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • beta-Glucans
  • carboxymethyl-beta-1,3-glucan
Topics
  • Animals
  • Antihypertensive Agents (pharmacology)
  • Baroreflex (drug effects)
  • Blood Pressure (drug effects)
  • Cardiomegaly (pathology)
  • Heart Rate (drug effects)
  • Hypertension (drug therapy, physiopathology)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Saccharomyces cerevisiae (chemistry)
  • Weight Gain (drug effects)
  • beta-Glucans (pharmacology)

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