Haemochromatosis in a kidney transplant recipient: a case report.

Abstract

BACKGROUND:

Iron overload is inevitably related to chronic kidney disease (CKD) treatment. Haemochromatosis leads to multiorgan damage and is associated with increased mortality. Primary haemochromatosis is the most common autosomal recessive disease in white populations. In most cases, the classic form of hereditary haemochromatosis is caused by mutations, mainly C282Y and H63D, in the haemochromatosis gene (HFE). Secondary haemochromatosis can be triggered by iron administration and blood transfusions. Haemochromatosis is rarely reported in kidney transplant recipients. Atypical factors may evoke haemochromatosis in patients without HFE mutations or other standard risk factors.

CASE PRESENTATION:

In the current study, we present a patient who started to have haemochromatosis symptoms after kidney transplantation. A 37-year-old man after kidney transplantation from a deceased donor was admitted to the hospital due to high serum ferritin levels and impaired graft function. The patient's past medical history included arterial hypertension, embolization of both renal arteries and necrosis of the left femoral head. Glomerulonephritis was suspected as a cause of CKD; however, severe kidney failure was diagnosed, kidney biopsy was not performed, and the patient started intermittent haemodialysis. While on dialysis to treat anaemia, the patient had received erythropoietin and iron intravenously, and the maximal serum ferritin level was 2115 ng/ml. After kidney transplantation, ferritin levels started to increase rapidly, with a maximum level of 9468 ng/ml one and a half years after surgery. His genetic study showed HFE C282Y heterozygosity. Symptoms of haemochromatosis, such as skin hyperpigmentation, elevated activity of aminotransferases, impaired glucose tolerance and heart failure, were observed. Therapeutic phlebotomy was started, and 36 procedures were performed. After treatment, graft function significantly improved, most haemochromatosis symptoms resolved, and the serum ferritin level significantly decreased.

CONCLUSIONS:

Haemochromatosis can occur in heterozygotic HFE patients after kidney transplantation. Iron administration, infections, type of immunosuppression and liver dysfunction should be considered potential triggers of haemochromatosis in this group of patients.

• Authors: Izabela Zakrocka, Iwona Baranowicz-Gąszczyk, Wojciech Załuska
• Journal: BMC nephrology (BMC Nephrol) Vol. 22 Issue 1 Pg. 201 (05 29 2021) ISSN: 1471-2369 [Electronic] England
• PMID: 34051741 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ferritins

Topics

• Adult
• Ferritins (blood)
• Hemochromatosis (etiology, genetics, therapy)
• Heterozygote
• Humans
• Kidney (diagnostic imaging)
• Kidney Transplantation (adverse effects)
• Liver (diagnostic imaging, pathology)
• Male
• Phlebotomy
• Tomography, X-Ray Computed