Abstract | BACKGROUND: METHODS:
Cancer patients attending the Fifth People's Hospital of Shenyang from April 2014 to March 2019 were enrolled according to inclusion and exclusion criteria. Cancer patients with AKI were divided into two groups according to the changes in renal function during the follow-up period: a renal function recovery group and a nonrecovery group. The differences in baseline data of the two groups were compared. Logistic univariate and multivariate regression analyses were conducted to determine the risk of renal function failure. RESULTS: A total of 3,127 cases were included. Among them, 659 cases (21.1%) had AKI, and 2,468 cases had no AKI. Among the 659 AKI patients, 473 (71.8%) patients' renal function recovered, while 186 (28.2%) did not. Logistic univariate and multivariate regression analyses indicated that age [odds ratio (OR) =1.133, 95% confidence interval (CI): 1.064-1.219], diabetes (OR =1.226, 95% CI: 1.093-1.385), chronic kidney disease (CKD) (OR =1.347, 95% CI: 1.108-1.624), hematological malignancies (OR =1.174, 95% CI: 1.063-1.311), chemotherapy (OR =1.119, 95% CI: 1.055-1.304), systolic blood pressure (OR =1.108, 95% CI: 1.062-1.267), serum creatinine (Scr) (OR =1.262, 95% CI: 1.105-1.446), and CysC (OR =1.416, 95% CI: 1.251-1.739) were related to the failure of renal function to recover after AKI. CONCLUSIONS: Baseline CysC level is associated with the occurrence of AKI in cancer patients and a failure to recover renal function during follow-up.
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Authors | Rui Li, Xia Wang, Xiaoqian Zhao, Xiaohong Zhang, Honghai Chen, Yue Ma, Yandong Liu |
Journal | Annals of palliative medicine
(Ann Palliat Med)
Vol. 10
Issue 2
Pg. 2158-2166
(Feb 2021)
ISSN: 2224-5839 [Electronic] China |
PMID | 33725771
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Cystatin C
- Creatinine
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Topics |
- Acute Kidney Injury
(etiology)
- Biomarkers
- Creatinine
- Cystatin C
- Humans
- Neoplasms
- Prognosis
- Retrospective Studies
- Risk Factors
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