Abstract | BACKGROUND: METHODS: HCC patients with PVTT who underwent LR from 2005 to 2012 from 6 hospitals were retrospectively studied. The long-term overall survival (OS) and recurrence-free survival (RFS) were compared between patients with or without splenomegaly, and between patients who did or did not undergo splenectomy for splenomegaly. Propensity score matching (PSM) analysis was performed to match patients in a 1:1 ratio. RESULTS: Of 716 HCC patients with PVTT who underwent LR, 140 patients had splenomegaly (SM group) and 576 patients had no splenomegaly (non-SM group). The SM group was further subdivided into 49 patients who underwent splenectomy (SPT group), and 91 patients who did not received splenectomy (non-SPT group). PSM matched 140 patients in the SM group, and 49 patients in the SPT group. Splenomegaly was an independent risk factor of poor RFS and OS. The OS and RFS rates were significantly better for patients in the non-SM group than the SM group (OS: P<0.001; RFS: P<0.001), and for patients in the SPT group than the non-SPT group (OS: P<0.001; RFS: P<0.001). CONCLUSIONS: Patients who had splenomegaly had significantly worse survival in HCC patients with PVTT. Splenectomy for splenomegaly significantly improved long-term survival in these patients.
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Authors | Zong-Tao Chai, Xiu-Ping Zhang, Min Shao, Jian-Yang Ao, Zhen-Hua Chen, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jian-Hua Lin, Kun-Peng Fang, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng |
Journal | Annals of translational medicine
(Ann Transl Med)
Vol. 9
Issue 3
Pg. 247
(Feb 2021)
ISSN: 2305-5839 [Print] China |
PMID | 33708874
(Publication Type: Journal Article)
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Copyright | 2021 Annals of Translational Medicine. All rights reserved. |