Abstract | BACKGROUND: RESULTS: Swabs from fifty-one suspected BU cases were sampled in the Amansie Central District from St. Peters Hospital (Jacobu) and through an active case surveillance. Forty of the samples were M. ulcerans (BU) positive. Secondary bacteria were identified in all sampled lesions (N = 51). The predominant bacteria identified in both BU and Non-BU groups were Staphylococci spp and Bacilli spp. The most diverse secondary bacteria were detected among BU patients who were not yet on antibiotic treatment. Fungal species identified were Candida spp, Penicillium spp and Trichodema spp. Selected secondary bacteria isolates were all susceptible to clarithromycin and amikacin among both BU and Non-BU patients. Majority, however, had high resistance to streptomycin. CONCLUSIONS: Microorganisms other than M. ulcerans colonize and proliferate on BU lesions. Secondary microorganisms of BU wounds were mainly Staphylococcus spp, Bacillus spp and Pseudomonas spp. These secondary microorganisms were less predominant in BU patients under treatment compared to those without treatment. The delay in healing that are experienced by some BU patients could be as a result of these bacteria and fungi colonizing and proliferating in BU lesions. Clarithromycin and amikacin are likely suitable drugs for clearance of secondary infection of Buruli ulcer.
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Authors | Elizabeth Gyamfi, Charles A Narh, Charles Quaye, Adiza Abbass, Bartholomew Dzudzor, Lydia Mosi |
Journal | BMC microbiology
(BMC Microbiol)
Vol. 21
Issue 1
Pg. 4
(01 05 2021)
ISSN: 1471-2180 [Electronic] England |
PMID | 33402095
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Amikacin
- Clarithromycin
- Streptomycin
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Topics |
- Adult
- Amikacin
(pharmacology)
- Anti-Bacterial Agents
(pharmacology)
- Bacillus
(classification, isolation & purification)
- Bacteria
(classification, drug effects, isolation & purification)
- Buruli Ulcer
(drug therapy, microbiology)
- Candida
(classification, isolation & purification)
- Clarithromycin
(pharmacology)
- Coinfection
(drug therapy, microbiology)
- Cote d'Ivoire
- Cross-Sectional Studies
- Female
- Fungi
(classification, drug effects, isolation & purification)
- Ghana
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Penicillium
(classification, isolation & purification)
- Staphylococcus
(classification, isolation & purification)
- Streptomycin
(pharmacology)
- Trichoderma
(classification, isolation & purification)
- Watchful Waiting
- Young Adult
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