Abstract | OBJECTIVE: METHODS: Fifty-three patients with RA/AS were treated with etanercept or certolizumab pegol for 1 year. Circulating oxLDL/β2-GPI complex (AtherOx), anti-Hsp60 IgG, and BNP8-29 fragment levels were assessed by ELISA. suPAR levels were determined by suPARnostic Quick Triage test. Flow-mediated vasodilation (FMD), carotid intima-media thickness (CIMT), and arterial pulse wave velocity (PWV) were determined by ultrasound. RESULTS: One-year anti-TNF treatment significantly decreased oxLDL/β2-GPI levels, as well as suPAR levels in patients with critically high suPAR levels at baseline. In RA, BNP levels were higher in seropositive vs seronegative patients. Serum levels of these vascular biomarkers variably correlated with lipids, anticitrullinated protein antibodies, rheumatoid factor, and C-reactive protein. CIMT positively correlated with BNP, and PWV with suPAR and anti-Hsp60, whereas FMD inversely associated with anti-Hsp60. In repeated measures ANOVA analysis, disease activity supported the effects of anti-TNF treatment on 12-month changes in oxLDL/β2-GPI. CIMT supported the effects of therapy on changes in anti-Hsp60 and suPAR. CONCLUSION: These biomarkers may be involved in the pathogenesis of atherosclerosis underlying RA/AS. TNF inhibition variably affects the serum levels of oxLDL/β2-GPI, suPAR, and BNP.
|
Authors | Anita Pusztai, Attila Hamar, Ágnes Horváth, Katalin Gulyás, Edit Végh, Nóra Bodnár, György Kerekes, Monika Czókolyová, Szilvia Szamosi, Levente Bodoki, Katalin Hodosi, Andrea Domján, Gábor Nagy, Ibolya Szöllősi, Luis R Lopez, Eiji Matsuura, Zoltán Prohászka, Sándor Szántó, Zoltán Nagy, Yehuda Shoenfeld, Zoltán Szekanecz, Gabriella Szűcs |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 48
Issue 6
Pg. 821-828
(06 2021)
ISSN: 0315-162X [Print] Canada |
PMID | 33323530
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2021 by the Journal of Rheumatology. |
Chemical References |
- Biomarkers
- Tumor Necrosis Factor Inhibitors
|
Topics |
- Arthritis, Rheumatoid
(drug therapy)
- Biomarkers
- Carotid Intima-Media Thickness
- Humans
- Necrosis
- Pulse Wave Analysis
- Spondylitis, Ankylosing
(drug therapy)
- Tumor Necrosis Factor Inhibitors
(therapeutic use)
|