Abstract | PURPOSE: Three human papillomavirus (HPV) vaccines are available against up to nine HPV types. In Sweden, from 2012, Gardasil was offered to 10-12 year old girls through the school-based vaccination program, and as catchup vaccination for women up to 26 years. To obtain a baseline, and follow HPV vaccination effects, during 2008-2018, cervical and oral HPV prevalence were followed at a youth clinic in Stockholm, and in 2013 for comparison oral HPV prevalence was examined in high-school youth in a middle-sized county in Sweden. METHODS: In this review, we discuss all our data with cervical and oral mouthwash samples that were collected and tested for 24-27 HPV types by a bead-based multiplex assay from 2008. RESULTS: Compared with 2008-2011, with ~ 35% HPV16 and > 60% high risk (HR) HPV cervical prevalence at the youth clinic, a decrease of vaccine HPV types was observed between 2013 and 2018, with e.g., HPV16 falling to 5% in catchup vaccinated women and 15-18% in nonvaccinated women. Most common cervical HR-HPV types were HPV39, 51, 52, 56, and 59 together accounting for ~ 10% of cervical cancer, and where only HPV52 is included in Gardasil-9. At baseline 2009-2011, oral HPV prevalence was ~ 10% in unvaccinated youth at the youth clinic, but after 2013 it dropped to < 2% at the youth clinic and high schools. CONCLUSION: To conclude, Gardasil HPV types have decreased, but it is still important to follow remaining HR-HPV types and cancer development, since there is an ongoing increase in the incidence of HPV-associated tonsillar and base of tongue cancer, and cervical cancer in Sweden.
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Authors | Juan Du, Andreas Ährlund-Richter, Anders Näsman, Tina Dalianis |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 303
Issue 2
Pg. 329-335
(02 2021)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 33247317
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
- Human Papillomavirus Recombinant Vaccine nonavalent
- Papillomavirus Vaccines
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Topics |
- Adolescent
- Adult
- Alphapapillomavirus
(immunology)
- Child
- Female
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
(immunology)
- Human papillomavirus 16
- Humans
- Incidence
- Papillomaviridae
(genetics, isolation & purification)
- Papillomavirus Infections
(diagnosis, epidemiology, prevention & control, virology)
- Papillomavirus Vaccines
(administration & dosage, adverse effects, immunology)
- Prevalence
- Sweden
(epidemiology)
- Uterine Cervical Neoplasms
(prevention & control, virology)
- Vaccination
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