Abstract |
The role of total parenteral nutrition (TPN) in cancer patients is controversial, but it may be a treatment option for some patients with indolent but advanced small intestinal neuroendocrine neoplasms (SI-NENs). The aim of this study is to investigate whether home TPN was associated with long-term survival and to assess the indications, duration and complications of TPN in patients with advanced SI-NENs. Patients with advanced SI-NENs who received home TPN were retrospectively included. Electronic records were reviewed for clinical information. Five patients receiving home TPN were identified out of 1011 patients with SI-NENs in our center. The median duration of TPN administration was 12 mo. Small bowel obstruction was the most common reason for TPN initiation. TPN-related complications included two catheter infections, one thrombosis and one episode of TPN-related transaminitis. At the last follow-up, three patients had died and two were alive. The median survival was 12 mo. Overall estimated 1-yr probability of survival on home TPN by Kaplan-Meier analysis was 40%. In conclusion, home TPN may be a treatment option in highly selected advanced SI-NEN patients with severe gastrointestinal tract dysfunction. The initiation of home TPN is associated with long-term survival (≥1 yr), and complication rates appear acceptable.
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Authors | Man Liu, Faidon-Marios Laskaratos, Jose Bennell, Jie Chen, Christos Toumpanakis, Dalvinder Mandair, Martyn Caplin |
Journal | Nutrition and cancer
(Nutr Cancer)
Vol. 73
Issue 9
Pg. 1638-1643
( 2021)
ISSN: 1532-7914 [Electronic] United States |
PMID | 32865033
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Humans
- Intestinal Neoplasms
(complications, therapy)
- Intestines
- Parenteral Nutrition, Home Total
- Parenteral Nutrition, Total
- Retrospective Studies
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