Objective: This study analyzes the expression level of miR-1180-3p and constructs the regulatory network of relevant
ceRNA by integrating the DNA methylation and gene expression profile of
hepatocellular carcinoma from the
Cancer Genome Atlas (TCGA). Methods: Firstly, the expression level of miR-1180-3p in
hepatocellular carcinoma and adjacent tissues was analyzed by TCGA database, and the differential expression of
lncrna and
mRNA was screened. Secondly, the LncBase database and the TargetScan database were used to predict the relationship between miR-1180-3p and
lncRNA and
mRNA, and the DNA methylation-mediated
lncRNA was screened by the DNA methylation profile of
lncRNA. Finally, Cytoscape software was used to construct miR-1180-3p relevant
ceRNA network, and WebGestalt website was used to perform GO and KEGG analysis of related
mRNA in
ceRNA. Results: Compared with patients with low expression of miR-1180-3p (mean overall survival duration, 5.69 ± 0.35 years), patients with high expression of miR-1180-3p had shorter overall survival time (mean overall survival duration, 3.99 ± 0.47 years), indicating that the high expression of miR-1180-3p was
hepatocellular carcinoma risk factor affecting the prognosis (HR = 1.28, 95% CI = 1.1 ~ 1.5, P < 0.01). A miR-1180-3p related
ceRNA regulatory network was constructed in this study, which contained 2 lncRNAs (F11-AS1 and LINC01511) and 37 mRNAs. Conclusion: This study has successfully constructed miR-1180-3p relevant
ceRNA regulatory network, and DNA methylation-mediated F11-AS1 and F11-AS1/miR-1180-3p/C11of54
ceRNA regulatory axis has played an important role in the occurrence and development of
hepatocellular carcinoma.