Abstract |
Thirty-seven million people in the United States are estimated to have chronic kidney disease (CKD). Hypertension (HTN) is the second leading risk factor for developing kidney disease. A recent study reported that increasing levels of β-hydroxybutyrate levels by administration of its precursor, 1,3-butanediol, decreased salt-induced HTN in male Dahl salt-sensitive (S) rats. The effect of 1,3-butanediol on hypertensive kidney disease in female rats or the absence of high salt has not been investigated. This study tested the hypothesis that 1,3-butanediol attenuates HTN and the progression of CKD in female S-SHR(11) rats. The S-SHR(11) strain is a congenic rat strain generated from genetic modification of the Dahl S rat, previously characterized as a model of accelerated renal disease. Rats received 1,3-butanediol (20% via drinking water) or control for 10 wk and were maintained on a 0.3% NaCl rodent diet (n = 12-14 rats/group). Blood pressure was measured after 6 and 9 wk of treatment by tail-cuff plethysmography; after 10 wk, urine and tissues were collected. Activity of the treatment was confirmed by measuring plasma β-hydroxybutyrate levels, which were greater in the treated group. The 1,3-butanediol-treated group had lower systolic blood pressure, proteinuria, plasma creatinine, and renal fibrosis after 9 wk of treatment compared with controls. The treated group had significantly smaller spleens and increased the renal anti-inflammatory molecules interleukin-10 and granulocyte-macrophage colony-stimulating factor, suggesting reduced inflammation. The present data demonstrate that 1,3-butanediol lowers blood pressure and renal injury in female rats and could be a novel nutritional intervention for the treatment of CKD.
|
Authors | Jeanne A Ishimwe, Michael R Garrett, Jennifer M Sasser |
Journal | American journal of physiology. Renal physiology
(Am J Physiol Renal Physiol)
Vol. 319
Issue 1
Pg. F106-F114
(07 01 2020)
ISSN: 1522-1466 [Electronic] United States |
PMID | 32508113
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Butylene Glycols
- 1,3-butylene glycol
|
Topics |
- Animals
- Blood Pressure
(drug effects)
- Butylene Glycols
(pharmacology, therapeutic use)
- Disease Progression
- Female
- Hypertension
(drug therapy, physiopathology)
- Kidney
(drug effects, physiopathology)
- Rats
- Rats, Inbred SHR
- Renal Insufficiency, Chronic
(drug therapy, physiopathology)
|