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Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.

Abstract
The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN.
AuthorsLixia Tang, Ke Li, Yan Zhang, Huifang Li, Ankang Li, Yuancheng Xu, Bing Wei
JournalScientific reports (Sci Rep) Vol. 10 Issue 1 Pg. 2440 (02 12 2020) ISSN: 2045-2322 [Electronic] England
PMID32051470 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Liposomes
  • Streptozocin
  • Quercetin
Topics
  • Animals
  • Antioxidants (administration & dosage, pharmacokinetics, therapeutic use)
  • Diabetes Mellitus, Experimental (chemically induced, complications, metabolism, pathology)
  • Diabetic Nephropathies (chemically induced, drug therapy, metabolism, pathology)
  • Kidney (drug effects, metabolism, pathology)
  • Liposomes
  • Male
  • Oxidative Stress (drug effects)
  • Quercetin (administration & dosage, pharmacokinetics, therapeutic use)
  • Rats
  • Rats, Sprague-Dawley
  • Streptozocin

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