Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT.

Abstract

Immunoglobulin G4 (IgG4)-related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using 68Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).

• Authors: Saurabh Arora, Nishikant A Damle, Rachna Meel, Sanjay Sharma, Seema Sen, Chandrasekar Bal, Kanak Lata, Sneha Prakash, Divya Yadav, Meivel Angamuthu
• Journal: Nuclear medicine and molecular imaging (Nucl Med Mol Imaging) Vol. 53 Issue 6 Pg. 432-435 (Dec 2019) ISSN: 1869-3474 [Print] Germany
• PMID: 31867079 (Publication Type: Journal Article)
• Copyright: © Korean Society of Nuclear Medicine 2019.