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Somatostatin Receptors (Somatostatin Receptor)

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Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.

Also Known As:

Somatostatin Receptor; Receptors, Somatostatin; Receptors, SRIH; SRIH Receptors; Receptor, Somatostatin; Receptors, Somatotropin Release Inhibiting Hormone

Networked: 1686 relevant articles (79 outcomes, 223 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 72216
  - Membrane Proteins: 4679
    - Cell Surface Receptors: 650

Experts

1.	Reubi, Jean Claude: 17 articles (02/2012 - 05/2002)
2.	Krenning, Eric P: 12 articles (09/2010 - 04/2002)
3.	Hofland, Leo J: 11 articles (12/2011 - 12/2002)
4.	Maecke, Helmut R: 9 articles (03/2012 - 02/2002)
5.	Lamberts, Steven W J: 9 articles (11/2009 - 12/2002)
6.	Waser, Beatrice: 8 articles (02/2012 - 11/2002)
7.	Hofland, L J: 8 articles (02/2012 - 04/2000)
8.	Pawlikowski, Marek: 8 articles (09/2011 - 01/2003)
9.	Schally, Andrew V: 8 articles (10/2009 - 02/2002)
10.	Schally, A V: 8 articles (01/2005 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "After the discovery of somatostatin receptors (SSTR) over-expression in this group of neoplasms, NET management has significantly improved. " 09/06/2007 - "Despite the differences in biological efficacy, the favorable binding affinity, tumor uptake, and tumor-to-background ratio results for both diastereomeric species predict that both are effective for imaging somatostatin receptor-positive tumors in vivo." 11/01/2003 - "These tumors may represent a potential target treatment with somatostatin receptor agonists with improved sst(3) activity." 02/01/2012 - "The aim of this study was to correlate immunohistochemistry using the new monoclonal anti-somatostatin receptor subtype 2A antibody UMB-1 with the gold standard in vitro method quantifying somatostatin receptor levels in tumor tissues. " 09/01/1996 - "This indicates that the sensitivity of the detection of somatostatin receptor-positive tumor by receptor scintigraphy may be improved by varying the mass of the radiopharmaceutical, which has also been confirmed in patient studies. " Order ALL the reference details at left...
2.	Neoplasm Metastasis (Metastasis) 01/01/2007 - "Predictive factors for tumour remission were high tumour uptake on somatostatin receptor scintigraphy and limited amount of liver metastases. " 04/20/2005 - "Higher remission rates were positively correlated with high uptake on pretherapy somatostatin receptor imaging and a limited number of liver metastases, whereas PD was significantly more frequent in patients with a low performance score and extensive disease. " 10/01/2006 - "Somatostatin receptor scintigraphy (SRS) holds great promise for detecting primary tumours and metastases. " 10/01/1999 - "The aim of this study was to compare prospectively somatostatin receptor scintigraphy (SRS) using 111n-pentetreotide with bone scintigraphy using 99mTc-hydroxymethylene diphosphonate for the detection of bone metastases. " 10/01/1999 - "4: somatostatin receptor scintigraphy and magnetic resonance imaging have higher sensitivity and predictive values for bone metastases than bone scanning; Study n. " Order ALL the reference details at left...
3.	Neuroendocrine Tumors (Neuroendocrine Tumor) 02/01/2010 - "Aim of this study was to evaluate the feasibility, the efficacy and the toxicity of this treatment in neuroendocrine tumors expressing somatostatin receptors relapsed or refractory to conventional therapies. " 11/01/2007 - "A multicentric study was designed to compare somatostatin receptor immunohistochemical expression with in vivo scintigraphic data and verify its usefulness in the clinical management of neuroendocrine tumors. " 09/01/2006 - "The aim of the study was to provide dosimetric data on intrahepatic (111)In-diethylenetriaminepentaacetic acid (DTPA)-D-Phe(1)-octreotide therapy for neuroendocrine tumors with overexpression of somatostatin receptors. " 01/01/2003 - "Many studies describe the sensitivities and specificities of computed tomography (CT), magnetic resonance imaging (MRI), and somatostatin receptor scintigraphy (SRS) in patients with gastrointestinal neuroendocrine tumors (GNT). " 05/01/1994 - "In this study 76 patients with immunohistologically proven neuroendocrine tumors were analysed by comparing somatostatin-receptor scintigraphy with conventional imaging techniques. " Order ALL the reference details at left...
4.	Carcinoid Tumor (Carcinoid) 08/01/2002 - "We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours and evaluating the extent of the disease. " 02/01/2001 - "This human transplantable carcinoid tumor, designated GOT1, grafted to nude mice, will give unique possibilities for studies of somatostatin receptor- and VMAT-mediated radionuclide uptake as well as for studies of secretory mechanisms." 08/01/2012 - "Diagnosis of an ectopic adrenocorticotropic hormonesecreting bronchial carcinoid by somatostatin receptor scintigraphy." 03/01/2012 - "In Canada, staging of carcinoid tumors is largely based on computed tomography (CT) imaging sometimes complemented with somatostatin receptor scintigraphy (SRS). " 09/01/2011 - "In conclusion, SPET/CT imaging was more useful to anatomically detect carcinoids either in abdomen or in thorax and specifically lesions not expressing somatostatin receptors, as compared to SPET alone." Order ALL the reference details at left...
5.	Gastrinoma 01/01/2006 - "We overviewed the recent development of curative surgery for gastrinoma that has been rapidly improved since the development of new localization techniques, especially the selective arterial secretagogue injection test (SASI test) and somatostatin receptor scintigraphy (SRS). " 04/01/2002 - "Endoscopic ultrasonography and somatostatin receptor scintigraphy are the gold standard for localization of gastrinomas. " 10/01/1999 - "1: somatostatin receptor scintigraphy is the most sensitive modality for detection of primary or metastatic gastrinomas; Study n. " 06/01/2005 - "EUS in conjunction with Somatostatin Receptor Scanning (SRS) has a combined sensitivity of 93% for gastrinomas. " 03/01/2002 - "Twenty-two years' survival of metastatic gastrinoma evidenced recently by somatostatin-receptor-specific scintigraphy." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Somatostatin (Somatotropin Release-Inhibiting Factor)
2.	Octreotide (Sandostatin)
3.	lanreotide (Somatuline)
4.	pentetreotide (OctreoScan)
5.	Hormones
6.	Messenger RNA (mRNA)
7.	Pentetic Acid (DTPA)
8.	(DOTA(0)-Phe(1)-Tyr(3))octreotide (SMT 487)
9.	Somatostatin Receptors (Somatostatin Receptor)
10.	yttrium(III)- 1,4,7,10- tetraazacyclotetradecane- N,N',N'',N'''- tetraacetic acid

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Palliative Care (Palliative Medicine)
5.	Aftercare (After-Treatment)

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