Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.

Abstract

INTRODUCTION:

Human papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome.

OBJECTIVES:

To critically evaluate a potential connection between HPV vaccination and the above-noted conditions.

METHODS:

We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders.

RESULTS:

At this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia.

CONCLUSION:

Certain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.

• Authors: Alexandru Barboi, Christopher H Gibbons, Felicia Axelrod, Eduardo E Benarroch, Italo Biaggioni, Mark W Chapleau, Gisela Chelimsky, Thomas Chelimsky, William P Cheshire, Victoria E Claydon, Roy Freeman, David S Goldstein, Michael J Joyner, Horacio Kaufmann, Phillip A Low, Lucy Norcliffe-Kaufmann, David Robertson, Cyndya A Shibao, Wolfgang Singer, Howard Snapper, Steven Vernino, Satish R Raj, American Autonomic Society
• Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (Clin Auton Res) Vol. 30 Issue 1 Pg. 13-18 (02 2020) ISSN: 1619-1560 [Electronic] Germany
• PMID: 31475305 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Papillomavirus Vaccines

Topics

• Autonomic Nervous System Diseases (chemically induced, diagnosis, epidemiology)
• Fatigue Syndrome, Chronic (chemically induced, diagnosis, epidemiology)
• Humans
• Papillomavirus Infections (epidemiology, prevention & control)
• Papillomavirus Vaccines (administration & dosage, adverse effects)
• Postural Orthostatic Tachycardia Syndrome (chemically induced, diagnosis, epidemiology)
• Primary Dysautonomias (chemically induced, diagnosis, epidemiology)
• Societies, Medical (trends)
• United States (epidemiology)