Abstract | BACKGROUND: AIMS AND OBJECTIVES: To identify characteristic features of a neurological syndrome (presentation pattern and tempo of illness- onset, duration, progression and response to treatment) which indicate a paraneoplastic etiology. MATERIALS AND METHODS: This is a retrospective study. Medical records of all patients who were discharged/ died in Neurology unit of a tertiary care center over a study period of two years with a diagnosis of Paraneoplastic neurological syndrome as per the diagnostic criteria given by F Graus et al1 were studied. RESULTS: Seven PNS cases were identified of which, five had peripheral and two had central nervous system syndrome consistent with the anatomical localisation. Painful pure motor quadriparesis was present in three cases. Subacute onset and rapid progression was seen in six out of seven patients. Ill sustained response to corticosteroid treatment was seen in three patients whereas the remaining four showed no response. In five patients, tumour was detected after the diagnosis of neurological syndrome, as against one patient which had an antecedent tumour and the remaining one patient had classical onconeural antibody without evidence of any detectable tumor. Average time to tumor diagnosis from neurological symptom was 3.5 months. CONCLUSION:
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Authors | Pawan Ojha, Kamlesh Jagiasi, Akash Chheda, Girish Soni, Dhanashree Peddawad, Nikhil Kadam, Sarika Patil |
Journal | The Journal of the Association of Physicians of India
(J Assoc Physicians India)
Vol. 66
Issue 9
Pg. 14-18
(Sep 2018)
ISSN: 0004-5772 [Print] India |
PMID | 31321924
(Publication Type: Journal Article)
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Copyright | © Journal of the Association of Physicians of India 2011. |
Topics |
- Aged
- Encephalitis
- Humans
- Nervous System Diseases
- Paraneoplastic Syndromes
- Paraneoplastic Syndromes, Nervous System
(diagnosis, etiology)
- Retrospective Studies
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