Abstract | BACKGROUND: METHODS: An age/sex matching plus propensity-scored logistic regression model incorporating variables related to the outcome and spironolactone treatment was created to compare patients treated with spironolactone for a 9-month period versus matched controls. A within-person analysis comparing changes in serum biomarker concentrations in the 9 months before versus after spironolactone treatment was also performed. RESULTS: Patients included in the between-person analysis (n=146) were well matched: the mean age was 63±7 years and 11% were woman. Serum concentrations of PIIINP and PICP rose in 'controls' and fell during spironolactone treatment (adjusted means +0.52 (-0.05 to 1.09) vs -0.41 (-0.97 to 0.16) ng/mL, p=0.031 for PIIINP and +4.54(-1.77 to 10.9) vs -6.36 (-12.5 to -0.21) ng/mL, p=0.023 for PICP). For the within-person analysis (n=173), spironolactone treatment was also associated with a reduction in PICP (beta estimate=-11.82(-17.53 to -6.10) ng/mL, p<0.001) but not in PIIINP levels. CONCLUSIONS:
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Authors | João Pedro Ferreira, Patrick Rossignol, Anne Pizard, Jean-Loup Machu, Timothy Collier, Nicolas Girerd, Anne-Cécile Huby, Arantxa Gonzalez, Javier Diez, Begoña López, Naveed Sattar, John G Cleland, Peter S Sever, Faiez Zannad |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 105
Issue 4
Pg. 307-314
(02 2019)
ISSN: 1468-201X [Electronic] England |
PMID | 30121630
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- Biomarkers
- Mineralocorticoid Receptor Antagonists
- Peptide Fragments
- Procollagen
- procollagen Type III-N-terminal peptide
- procollagen type I carboxy terminal peptide
- Spironolactone
- Collagen
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Topics |
- Aged
- Biological Availability
- Biomarkers
(blood)
- Blood Pressure
(drug effects)
- Collagen
(biosynthesis, metabolism)
- Drug Monitoring
(methods)
- Drug Resistance
- Female
- Heart Failure
(etiology, metabolism, prevention & control)
- Humans
- Hypertension
(complications, diagnosis, drug therapy, metabolism)
- Male
- Middle Aged
- Mineralocorticoid Receptor Antagonists
(administration & dosage, pharmacokinetics)
- Outcome Assessment, Health Care
- Peptide Fragments
(blood)
- Procollagen
(blood)
- Spironolactone
(administration & dosage, pharmacokinetics)
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