Infection-associated epigenetic alterations in gastric cancer: New insight in cancer therapy.

Abstract

Gastric cancer risk is higher for malignancies motivated by bacterial and viral infections. Epigenetic abnormalities including DNA methylation, histone modifications, and noncoding RNAs are important regulatory key players in gastric cancer development in infected patients. Epigenetic memory restoration is an extremely interesting phenomenon which should be considered in therapeutic approaches. In vitro and in vivo antiviral treatments in combination with epigenetic therapeutic strategies along with standard chemotherapy revealed promising outcomes in gastric cancer prevention and treatment. This review summarizes our current understanding of the gastric cancer infections and epigenetic alterations caused by these agents. We focus on studies highlighting recent advances in epigenetic restoration by target specific drugs and present also a comprehensive overview of effective antiviral drug treatments against gastric cancer.

• Authors: Sadegh Fattahi, Mohadeseh Kosari-Monfared, Elham Ghadami, Monireh Golpour, Parastoo Khodadadi, Mohammad Ghasemiyan, Haleh Akhavan-Niaki
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 233 Issue 12 Pg. 9261-9270 (12 2018) ISSN: 1097-4652 [Electronic] United States
• PMID: 30076708 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents
• Antiviral Agents
• RNA, Untranslated

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Antiviral Agents (therapeutic use)
• DNA Methylation (drug effects)
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic (drug effects)
• Histone Code (drug effects)
• Humans
• RNA, Untranslated (genetics)
• Stomach Neoplasms (drug therapy, microbiology, virology)