Acquisition of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Infection in a Patient Taking Preexposure Prophylaxis.

Abstract

We report a case indicating that acquisition of multidrug-resistant human immunodeficiency (HIV) virus type 1 during preexposure prophylaxis with combination tenofovir disoproxil fumarate and emtricitabine or evolution of resistance after HIV seroconversion remains a risk.

• Authors: Donn J Colby, Eugene Kroon, Carlo Sacdalan, Monica Gandhi, Robert M Grant, Praphan Phanuphak, Jintanat Ananworanich, Merlin L Robb, Nittaya Phanuphak
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 67 Issue 6 Pg. 962-964 (08 31 2018) ISSN: 1537-6591 [Electronic] United States
• PMID: 29961859 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anti-HIV Agents
• RNA, Viral
• Tenofovir
• Emtricitabine

Topics

• Adult
• Anti-HIV Agents (therapeutic use)
• Drug Resistance, Multiple, Viral
• Emtricitabine (therapeutic use)
• HIV Infections (diagnosis, prevention & control)
• HIV Seropositivity
• HIV-1 (isolation & purification)
• Humans
• Male
• Medication Adherence
• Pre-Exposure Prophylaxis
• RNA, Viral (genetics)
• Tenofovir (therapeutic use)
• Thailand