Incidental Detection of Parathyroid Adenoma on Somatostatin Receptor PET/CT and Incremental Role of 18F-Fluorocholine PET/CT in MEN1 Syndrome.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid involvement is the most common manifestation and usually the first clinical involvement in MEN1 syndrome, followed by gastroentero-pancreatic neuroendocrine tumors (NETs). Here we present a case where the patient initially presented with metastatic gastric NET and a single parathyroid adenoma was detected incidentally on 68Ga-DOTANOC PET/CT done as part of post 177Lu-DOTATATE therapy (PRRT) follow-up. Further 18F-fluorocholine PET/CT showed four adenomas for which the patient subsequently underwent subtotal parathyroidectomy.

• Authors: Saurabh Arora, Nishikant Avinash Damle, Averilicia Passah, Madhav Prasad Yadav, Sanjana Ballal, Vivek Aggarwal, Yashdeep Gupta, Praveen Kumar, Madhavi Tripathi, Chandrasekhar Bal
• Journal: Nuclear medicine and molecular imaging (Nucl Med Mol Imaging) Vol. 52 Issue 3 Pg. 238-242 (Jun 2018) ISSN: 1869-3474 [Print] Germany
• PMID: 29942404 (Publication Type: Case Reports)