Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.

Abstract

Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes. Amenamevir exhibits anti-VZV and anti-HSV activity while pritelivir only has anti-HSV activity. A clinical trial of amenamevir for herpes zoster has been completed, and amenamevir has been licensed and successfully used in 20,000 patients with herpes zoster so far in Japan. We have characterized the features of the antiviral action of amenamevir and, unlike acyclovir, the drug's antiviral activity is not influenced by the viral replication cycle. Amenamevir is opening a new era of antiherpes therapy.

• Authors: K Shiraki
• Journal: Drugs of today (Barcelona, Spain : 1998) (Drugs Today (Barc)) Vol. 53 Issue 11 Pg. 573-584 (Nov 2017) ISSN: 1699-3993 [Print] Spain
• PMID: 29451274 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2017 Clarivate Analytics.

Chemical References

• ASP2151
• Antiviral Agents
• Oxadiazoles
• Pyridines
• Sulfonamides
• Thiazoles
• Viral Proteins
• pritelivir
• DNA Primase
• helicase-primase, Human herpesvirus 1
• DNA Helicases

Topics

• Animals
• Antiviral Agents (pharmacology)
• DNA Helicases (antagonists & inhibitors)
• DNA Primase (antagonists & inhibitors)
• Drug Resistance, Viral
• Herpes Zoster (drug therapy, virology)
• Herpesvirus 3, Human (enzymology, isolation & purification)
• Humans
• Oxadiazoles (pharmacology)
• Pyridines (pharmacology)
• Sulfonamides
• Thiazoles (pharmacology)
• Viral Proteins (antagonists & inhibitors)