Objective: To analyze the clinical characteristics of
IgG4-related disease (IgG4-RD)so as to improve the understanding of
IgG4-RD in China. Methods:
IgG4-RD patients were recruited from Peking Union Medical College Hospital between January 2011 and January 2016. All patients were followed-up for more than 6 months. The demographic characteristics, symptoms, organ involvements, laboratory examinations and treatment efficacy were evaluated and analyzed. Results: A total of 346 patients were finally enrolled, including 230 males (66.5%) and 116 females (33.5%). The mean age of disease onset was (53.8±14.2) years old. The mostly common involved organs were lymph nodes (56.4%) and submandibular glands (52.6%). Other affected organs and manifestations included: swelling of the lacrimal glands (46.5%),
autoimmune pancreatitis (38.4%), pulmonary involvement (28.0%),
sclerosing cholangitis (25.4%), naso-
sinusitis (23.4%), parotid gland swelling (21.7%),
retroperitoneal fibrosis (19.9%), large arteries involvement (9.5%), kidney involvement (obstructive nephropathy caused by
retroperitoneal fibrosis was excluded) (6.9%), skin lesions (6.4%). Rare features consisted of thyroid glands, pituitary glands, gastrointestinal tract,
pachymeningitis, pericardium,
sclerosing mediastinitis and
orchitis. The majority of patients had multi-organ involvement, such as 74.3% patients with 3 and more, 18.2% and 7.5% patients with 2 and single organ involvement respectively. The average
IgG4-RD responder index (IgG4-RD RI) was 13.21±5.70. History of
allergy was found in 172 (49.7%) patients. As to the laboratory tests, elevated serum
IgG4 levels were confirmed in 285 (94.1%) patients, which was positively correlated with
IgG4-RD RI. There were 33.5% patients receiving monotherapy of
glucocorticoid, 52.6% treated with
glucocorticoids combined with
immunosuppressive agents, 4.9% patients with
immunosuppressant only, and 9.0% patients with mild disease not receiving medication. The majority (336, 97.1%) patients improved the above regimens. Conclusion:
IgG4-RD is a systemic fibro-inflammatory disease with multiple organ involvement. The mostly common involved organs include lymph node, submandibular glands, and pancreas.
Glucocorticoids and
immunosuppressive agents were effective for
IgG4-RD.