After
heart disease and combined forms of
cancer,
stroke is the leading cause of death in the United States. Currently,
tissue-plasminogen activator (tPA) thrombolysis is the only
thrombolytic therapy that has been shown to improve patient outcome. Presently, the only antithrombotic
drug treatment that has proven effective at improving
acute ischemic stroke patient outcome is
aspirin administration. Despite these studies, no clinical trials have yet demonstrated a reliably effective pharmacological treatment. Areas covered: We conducted a search of recent
drug studies for
ischemic stroke on clinicaltrials.gov in addition to a literature search for
acute ischemic stroke therapy using PubMed. This review details our findings of recent advancements in the pharmacological treatment of
acute ischemic stroke. Expert commentary: We concluded that recent attempts to establish new pharmacological treatment protocols for
acute ischemic stroke have had limited success, but many Phase III and Phase IV clinical trials demonstrate promise. Moreover, several studies have demonstrated the efficacy of dual-antiplatelet
therapies at reducing risk of secondary
stroke. Studies for novel therapeutic targets for neuroprotection have been largely unsuccessful. Some trials had positive results; however, there is much room for improvement and other studies show promise in their preliminary stages.