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Thrombolytic Therapy

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Use of infusions of fibrinolytic agents to destroy or dissolve thrombi in blood vessels or bypass grafts.

Also Known As:

Therapeutic Thrombolysis; Therapy, Fibrinolytic; Therapy, Thrombolytic; Fibrinolytic Therapies; Therapeutic Thrombolyses; Therapies, Fibrinolytic; Therapies, Thrombolytic; Thrombolyses, Therapeutic; Thrombolytic Therapies; Fibrinolytic Therapy; Thrombolysis, Therapeutic

Networked: 5953 relevant articles (461 outcomes, 786 trials/studies) for this Therapy, Comments

Relationship Network

Therapy Context: Research Results

Therapeutics: 10073
- Drug Therapy: 147948
  - Thrombolytic Therapy: 5953
    - Hirudin Therapy: 7

Experts

1.	Gibson, C Michael: 17 articles (11/2012 - 10/2002)
2.	Cannon, Christopher P: 17 articles (08/2009 - 10/2002)
3.	Antman, Elliott M: 15 articles (07/2009 - 10/2002)
4.	Murphy, Sabina A: 14 articles (04/2008 - 10/2002)
5.	Braunwald, Eugene: 13 articles (01/2009 - 10/2002)
6.	Sabatine, Marc S: 12 articles (08/2009 - 01/2005)
7.	American College of Chest Physicians: 10 articles (02/2012 - 06/2008)
8.	Nallamothu, Brahmajee K: 10 articles (01/2010 - 10/2003)
9.	Krumholz, Harlan M: 9 articles (12/2009 - 09/2002)
10.	Armstrong, Paul W: 8 articles (03/2012 - 02/2002)

Related Diseases

1.	Myocardial Infarction 12/01/2010 - "It is known that the efficacy of thrombolytic therapy in ST-segment elevation myocardial infarction (STEMI) is highly time dependent with the best efficacy when given within the so-called golden hour. " 02/01/2008 - "Although primary coronary angioplasty seems to be the best treatment in acute myocardial infarction (MI), thrombolytic therapy still remains the most common reperfusion strategy particularly in smaller centers. " 05/25/2005 - "This article examines thrombolytic therapy, the first-line treatment for patients presenting with acute myocardial infarction in most UK hospitals. " 06/01/1996 - "These observational data, if replicated, suggest that in patients with acute myocardial infarction, thrombolytic therapy may be most effective in current smokers, whereas nonsmokers and ex-smokers may require other management strategies, such as emergency percutaneous transluminal coronary angioplasty." 12/01/1994 - "Thrombolytic therapy has been proven to be highly effective and safe in patients presenting with acute myocardial infarction. " Order ALL the reference details at left...
2.	Stroke (Strokes) 12/01/2010 - "Only the latter has been proven to be effective in larger randomized trials and is a Class 1/Level A recommendation in national or international guidelines.(1) This review summarizes the evidence for thrombolytic therapy of acute ischemic stroke with emphasis on progress regarding the approved intravenous treatment. " 09/01/2009 - "Thrombolytic therapy has been proven to be beneficial in selected patients with ischaemic strokes. " 01/01/1993 - "Emergency cerebral angiography, which can be carried out relatively safely, adds important information about the nature and extent of the arterial occlusions, and the recanalization efficacy of fibrinolytic therapy for patients with acute stroke. " 01/01/2012 - "In patients with stroke attributable to ICA occlusion, thrombolytic therapy results in a significant reduction in the proportion of patients dependent in activities of daily living. " 05/01/2008 - "Results of our recent pilot clinical trial suggest that the efficacy of thrombolytic therapy in acute ischemic stroke may be enhanced by the coadministration of high-dose albumin. " Order ALL the reference details at left...
3.	Thrombosis (Thrombus) 09/16/2008 - "The optimal management of the right heart thromboemboli remains unclear, but thrombolytic therapy with rt-PA appears to be rapidly effective in most patients resulting with complete resolution of the thrombus and improvement of pulmonary perfusion. " 01/01/2005 - "Consensus on optimal treatment continues to be hampered by a lack of randomized trials, but recent studies demonstrate the efficacy of thrombolytic therapy in acute thrombosis, and the apparent safety and benefit of anticoagulation in patients with chronic portal vein thrombosis." 01/01/1994 - "The paper reports a case of a positive response to fibrinolytic therapy with complete lysis of the thrombus in the left internal carotid artery (ICA) and significant reduction of the baseline neurological deficiency. " 04/01/2002 - "We report the successful management of acute portal vein thrombosis with percutaneous transphepatic thrombolytic therapy. " 02/01/1994 - "Local thrombolytic therapy may be beneficial for other patients with rapid neurologic deterioration caused by extensive thrombosis of superficial and deep venous structures." Order ALL the reference details at left...
4.	Pulmonary Embolism 12/01/2009 - "Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy." 09/01/1998 - "This case suggests that delayed thrombolytic therapy in patients with massive pulmonary embolism can still be beneficial in selected cases, even if given more than 2 weeks after symptom onset." 06/01/1996 - "We found a significant ABD-assisted right ventricular hypokinetic regression after thrombolytic therapy in acute pulmonary embolism but could not demonstrate a linear relation between improvement in early right ventricular function and angiography." 06/01/1989 - "Many investigators have reported about beneficial results with thrombolytic therapy in patients with acute pulmonary embolism. " 04/15/1992 - "To determine whether thrombolytic therapy reduces the rate of death or complications in patients with acute pulmonary embolism and whether a particular thrombolytic regimen is more effective than others. " Order ALL the reference details at left...
5.	Hemorrhage 11/01/2012 - "We initially performed percutaneous transluminal angioplasty with thrombolytic therapy, but had to cease thrombolytic therapy due to upper gastrointestinal bleeding of Dieulafoy's lesion, nevertheless, achieved good results after revascularization by Fogarty embolectomy." 12/19/1996 - "Despite the fact that each of the third-generation drugs has shown considerable potential with regard to improving the efficacy of thrombolytic therapy, the risk of intracranial bleeding remains problematic and will need to be assessed in large, randomized trials." 09/01/1994 - "Although safe and effective, thrombolytic therapy is relatively contraindicated within 10 days of major surgery due to the risk of bleeding. " 11/19/1988 - "Our experience confirms the reduced incidence of allergic side effects (3.5%), major bleeding (0.3%) and minor bleeding (2.9%) during or after thrombolytic therapy." 12/01/2003 - "However, primary percutaneous coronary intervention (PCI) is associated with improved outcomes and less bleeding complications compared with fibrinolytic therapy, but it is not widely available. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Tissue Plasminogen Activator (Alteplase)
2.	Streptokinase
3.	Urokinase-Type Plasminogen Activator (Urokinase)
4.	Heparin (Liquaemin)
5.	Aspirin (Acetylsalicylic Acid)
6.	Fibrinolytic Agents (Antithrombotic Agents)
7.	glucuronyl glucosamine glycan sulfate (Vessel)
8.	Fibrin
9.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
10.	Plasminogen Activators (Plasminogen Activator)

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
3.	Catheters
4.	Cardiopulmonary Resuscitation (CPR)
5.	Transplants (Transplant)

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