Immunological evaluation of peptide vaccination for cancer patients with the HLA -A11+ or -A33+ allele.

Abstract

The HLA-A11 or -A33 allele is found in approximately 18% or 10% of the Asian population, respectively, but each of which is a minor allele worldwide, and therefore no clinical trials were previously conducted. To develop a therapeutic peptide vaccine for each of them, we investigated immunological responses of advanced cancer patients with the HLA-A11+ /A11+ (n = 18) or -A33+ /A33+ (n = 13) allele to personalized peptide vaccine (PPV) regimens. The primary sites of HLA-A11+/A11+ or -A33+/A33+ patients were the colon (n = 4 or 2), stomach (2 or 3), breast (3 or 2), lung and pancreas (2 or 2), and so on. For PPV, a maximum of four peptides were selected from nine different peptides capable of binding to HLA-A11 and -A33 molecules based on the pre-existing peptide-specific IgG responses. There were no severe adverse events related to PPV. At the end of the first cycle, peptide-specific CTL responses were augmented in 4/12 or 2/9 of HLA-A11+ /A11+ or -A33+ /A33+ patients, while peptide-specific IgG responses were augmented in 6/14 or 4/10 patients, respectively. Clinical responses consisted of four stable diseases and 14 progressive diseases in HLA-A11+ /A11+ patients, versus seven and six in -A33+ /A33+ patients, respectively. Further clinical study of PPV could be recommended because of the safety and positive immunological responses.

• Authors: Shinjiro Sakamoto, Satoko Matsueda, Shinzo Takamori, Uhi Toh, Masanori Noguchi, Shigeru Yutani, Akira Yamada, Shigeki Shichijo, Teppei Yamada, Shigetaka Suekane, Kouichiro Kawano, Masayasu Naitou, Tetsuro Sasada, Noboru Hattori, Nobuoki Kohno, Kyogo Itoh
• Journal: Cancer science (Cancer Sci) Vol. 108 Issue 4 Pg. 598-603 (Apr 2017) ISSN: 1349-7006 [Electronic] England
• PMID: 28178396 (Publication Type: Journal Article)
• Copyright: © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• Cancer Vaccines
• Epitopes, T-Lymphocyte
• HLA-A Antigens
• Immunoglobulin G
• Vaccines, Subunit
• Interferon-gamma

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Amino Acid Sequence
• Anemia (etiology)
• Cancer Vaccines (administration & dosage, adverse effects, immunology)
• Epitopes, T-Lymphocyte (immunology, metabolism)
• HLA-A Antigens (genetics, immunology)
• Humans
• Immunoglobulin G (immunology)
• Interferon-gamma (immunology, metabolism)
• Kaplan-Meier Estimate
• Leukopenia (etiology)
• Middle Aged
• Neoplasms (genetics, immunology, therapy)
• Retrospective Studies
• T-Lymphocytes, Cytotoxic (immunology, metabolism)
• Vaccination (adverse effects, methods)
• Vaccines, Subunit (administration & dosage, adverse effects, immunology)
• Young Adult