Long-Term Extensions of Randomized Vaccination Trials of ACC-001 and QS-21 in Mild to Moderate Alzheimer's Disease.

Abstract

OBJECTIVES:

Long-term safety and tolerability of ACC-001 (vanutide cridificar), an antiamyloid- beta therapeutic vaccine, was evaluated in subjects with mild to moderate Alzheimer's disease.

DESIGN:

Phase 2a extension studies of randomized parent trials were conducted in the United States, European Union, and Japan.

METHODS:

Four immunizations of ACC-001 were administered at the same 3 dose levels (3, 10, and 30 μg) to subjects randomized in the parent studies; ACC-001 was administered with QS-21 adjuvant. Safety, tolerability, and immunogenicity were assessed during active treatment and 6-month follow-up.

RESULTS:

ACC-001 + QS-21 was well tolerated in the United States (N=110) and European Union (N=50), and Japan (N=53) extension studies; safety profile was similar to that observed in the parent studies, and no new safety signals were identified. Overall, injection site reactions were the most common adverse event in these studies. Anti-amyloid antibody titers were elicited in all groups, with the highest titers observed in subjects who received ACC-001 + QS-21 in both the parent and extension studies.

CONCLUSIONS:

Long-term exposure to ACC-001 + QS-21 was well tolerated in subjects with Alzheimer's disease, suggesting that side effects do not pose a principal limitation for anti-amyloid active immunotherapy. The highest anti-amyloid-beta IgG titers are elicited during long-term therapy with ACC-001 + QS-21 compared with other regimens.

• Authors: Michael Hull, Carl Sadowsky, Heii Arai, Ghislaine Le Prince Leterme, Ann Holstein, Kevin Booth, Yahong Peng, Tamotsu Yoshiyama, Hideo Suzuki, Nzeera Ketter, Enchi Liu, J Michael Ryan
• Journal: Current Alzheimer research (Curr Alzheimer Res) Vol. 14 Issue 7 Pg. 696-708 ( 2017) ISSN: 1875-5828 [Electronic] United Arab Emirates
• PMID: 28124589 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Amyloid beta-Peptides
• Recombinant Fusion Proteins
• Saponins
• saponin QA-21V1
• vanutide cridificar

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (immunology, therapy)
• Amyloid beta-Peptides (immunology)
• Dose-Response Relationship, Immunologic
• Europe
• Female
• Humans
• International Cooperation
• Japan
• Longitudinal Studies
• Male
• Mental Status Schedule
• Middle Aged
• Recombinant Fusion Proteins (therapeutic use)
• Saponins (therapeutic use)
• Treatment Outcome
• United States
• Vaccination (methods)