Severe candida laryngitis in a patient with rheumatoid arthritis treated with adalimumab.

Abstract

Rheumatoid arthritis is a chronic erosive rheumatic disease that can present with polyarticular involvement. Anti-TNF-alpha drugs are used in cases that are resistant to traditional disease-modifying antirheumatic drugs (DMARDs). Anti-TNF-alpha drugs are groundbreaking drugs, the efficacy of which has been proven in the treatment of rheumatoid arthritis. However, the data concerning safety remain limited and contradictory. The risk of tuberculosis reactivation, various infections, as well as lymphoproliferative disease and/or secondary malignancy is a matter of discussion. In this report, we report a 52-year-old male patient using adalimumab for active rheumatoid arthritis who presented to our polyclinic with generalized mouth and throat sores, hoarseness, and swallowing difficulty. Candida laryngitis was detected in the laryngoscopy and culture samples. Adalimumab was discontinued, and the infection was controlled with anti-fungal treatment.

• Authors: Şenol Kobak, Hatice Yılmaz, Oğuz Güçlü, Zerrin Öğretmen
• Journal: European journal of rheumatology (Eur J Rheumatol) Vol. 1 Issue 4 Pg. 167-169 (Dec 2014) ISSN: 2147-9720 [Print] Turkey
• PMID: 27708907 (Publication Type: Journal Article)