Abstract | BACKGROUND AND PURPOSE: METHODS: To determine the relative roles of the KD and PUFAs in an animal model, we induced epilepsy in juvenile rats (P29-35) using intraperitoneal kainic acid (KA). KA caused status epilepticus in all rats. Two days after KA, rats were randomized to one of 4 dietary groups: Control diet; PUFA diet; KD; or KD plus PUFA. All diets were administered isocalorically at 90% of the rat recommended daily calorie requirement. Spontaneous recurrent seizures (SRS) were assessed for 3 months after diet randomization. RESULTS: Rats receiving the KD or KD-PUFA diet had significantly fewer SRS than those receiving the Control diet or PUFA diet. The PUFA diet did not reduce SRS compared to the Control diet. CONCLUSIONS: In the KA epilepsy model, the KD protects against SRS occurrence but dietary enhancement with PUFA does not afford additional protection against spontaneous seizures.
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Authors | Simone M Dustin, Carl E Stafstrom |
Journal | Journal of epilepsy research
(J Epilepsy Res)
Vol. 6
Issue 1
Pg. 1-7
(Jun 2016)
ISSN: 2233-6249 [Print] Korea (South) |
PMID | 27390673
(Publication Type: Journal Article)
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