Abstract | BACKGROUND: METHODS: This is a retrospective observational comparative cohort study conducted in two independent cohorts, one treated without and one treated with a local infiltration analgesia protocol, containing a total of 744 patients with a mean age of 68years (42 to 89) and 68years (21 to 88) respectively with a follow-up of 12months. RESULTS: No statistical difference in bradycardia during surgery, post-operative cardiovascular complications, and mortality was found after use of LIA. A statistically significant lower incidence of hypotension was found in the LIA group (P<0.01). This result has to be interpreted with care, due to the use of adrenaline in the LIA mixture, which could mask possible hypotension. No statistical difference was found in the occurrence of hypertension or tachycardia, despite the addition of adrenaline to the LIA mixture. No difference in mortality was found between the two groups (P=0.11). CONCLUSION:
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Authors | Joost R C Lameijer, Frederik Verboom, Joost Grefkens, Joris Jansen |
Journal | The Knee
(Knee)
Vol. 23
Issue 5
Pg. 877-82
(Oct 2016)
ISSN: 1873-5800 [Electronic] Netherlands |
PMID | 27345630
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
Chemical References |
- Amides
- Analgesics, Opioid
- Anesthetics, Local
- Vasoconstrictor Agents
- Ropivacaine
- Epinephrine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Amides
(administration & dosage, adverse effects)
- Analgesics, Opioid
(therapeutic use)
- Anesthetics, Local
(administration & dosage, adverse effects)
- Arthroplasty, Replacement, Knee
(adverse effects, methods)
- Cardiovascular Diseases
(etiology)
- Cohort Studies
- Epinephrine
(administration & dosage, adverse effects)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(diagnosis, prevention & control)
- Retrospective Studies
- Ropivacaine
- Vasoconstrictor Agents
(administration & dosage, adverse effects)
- Young Adult
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