Ropivacaine (Naropin)

An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons.

Also Known As:

Naropin; 1-Propyl-2',6'-pipecoloxylidide; AL 381; AL-381; LEA 103; LEA-103; Naropeine; Ropivacaine Hydrochloride; Ropivacaine Monohydrochloride; Ropivacaine Monohydrochloride, (S)-isomer; 1 Propyl 2',6' pipecoloxylidide; AL381; LEA103; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-

Networked: 1907 relevant articles (280 outcomes, 460 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - Ropivacaine: 1907
- Amides: 2428
  - Anilides: 22
    - Ropivacaine: 1907

Experts

1.	Ilfeld, Brian M: 17 articles (01/2022 - 06/2002)
2.	Casati, A: 14 articles (07/2007 - 01/2000)
3.	Fanelli, G: 10 articles (07/2007 - 01/2000)
4.	Borgeat, Alain: 9 articles (11/2014 - 02/2002)
5.	Fassoulaki, Argyro: 8 articles (07/2019 - 11/2005)
6.	Loland, Vanessa J: 8 articles (06/2017 - 11/2008)
7.	Mariano, Edward R: 7 articles (10/2021 - 03/2007)
8.	Gupta, Anil: 7 articles (01/2020 - 08/2002)
9.	Luo, Fang: 6 articles (12/2022 - 01/2019)
10.	Fanelli, Guido: 6 articles (01/2017 - 04/2002)

Related Diseases

1.	Pain (Aches) 11/01/2022 - "Ropivacaine in the distending fluid during hysteroscopy is associated with a significant reduction in pain within a few hours after hysteroscopy with no remarkable adverse effects." 10/01/2022 - "We hypothesized that intraoperative topical intra-tunnel irrigation with ropivacaine would result in a significant reduction in pain scores in the postoperative period. " 08/01/2016 - "Patients treated with pure PRP showed no significantly improved function at 3, 6, and 24 months after arthroscopic repair compared with control patients receiving ropivacaine; however, a similar pain reduction was documented in both groups. " 05/01/2009 - "Continuous ropivacaine perineural infusion (n = 15) produced a statistically and clinically significant reduction in average pain (median [10th-90th percentile]) on POD 1 compared with saline infusion (n = 15) after initial ropivacaine bolus (0.0 [0.0-5.0] versus 3.0 [0.0-6.0], respectively; P < 0.001). " 04/01/2006 - "The pain assessments upon movement of the operated joint were significantly greater after 24 hours in the group receiving a single dose of ropivacaine to block the sciatic nerve. "
2.	Postoperative Pain 10/01/2022 - "Postoperative pain with ropivacaine was significantly more relieved compared with that without ropivacaine in both groups (p < 0.05). " 01/01/2002 - "Ropivacaine 1 mg x ml(-1) showed less efficacy while the use of ropivacaine 3 mg x ml(-1) was associated with a higher incidence of motor block with minimal improvement in postoperative pain relief." 09/01/2017 - "This trial investigated whether ropivacaine alone is at least as effective for postoperative pain relief after LIA. " 01/01/2022 - "We found that intra-sheath injection of ropivacaine of the rectus abdomen was effective in reducing postoperative pain. " 02/01/2017 - "This study uniquely analyzed the efficacy of a single injection of caudal epidural ropivacaine in providing postoperative pain relief. "
3.	Wounds and Injuries (Trauma) 03/01/2013 - "The aim of this prospective, randomized, double-blind, placebo controlled trial was to evaluate the safety and efficacy of continuous ropivacaine infusion of into the sternal wound. " 12/01/2012 - "This trial sought to determine the efficacy of ropivacaine wound infusion following laparoscopic colonic surgery. " 01/01/2004 - "The pharmacokinetics and efficacy of ropivacaine continuous wound instillation after spine fusion surgery." 01/01/2022 - "In the present study, we found that ropivacaine delayed wound closure in vivo. " 01/01/2017 - "Efficacy and safety of 0.75% ropivacaine instillation into subinguinal wound in patients after bilateral microsurgical varicocelectomy: a bi-center, randomized, double-blind, placebo-controlled trial."
4.	Cataract (Cataracts) 06/01/1999 - "We conclude that 1% ropivacaine is a suitable agent for single injection peribulbar anaesthesia for cataract surgery." 06/01/2020 - "Efficacy and safety of ropivacaine HCl in peribulbar anaesthesia for cataract surgery in patients with myotonic dystrophy type 1." 03/01/2007 - "Deep-topical anaesthesia with ropivacaine or lidocaine was equally effective in providing anaesthesia with sufficient quality for cataract surgery." 12/01/2011 - "Cataract surgery complications: an in vitro model of toxic effects of ropivacaine and lidocaine." 06/01/2006 - "Levobupivacaine (0.5%) has better anaesthetic properties with respect to 0.75% ropivacaine and is well-suited for peribulbar block in cataract surgery."
5.	Inguinal Hernia (Direct Inguinal Hernia) 06/01/2023 - "This study aimed to determine the appropriate ropivacaine concentration for ultrasound-guided RSB in children undergoing laparoscopic inguinal hernia repair. " 04/01/2020 - "In a prospective, randomized, controlled study, 112 children of age 2-8 years and ASA grade I and II, undergoing elective inguinal hernia surgery were randomly allocated into two groups: Group T (n = 56) received USG-guided TAP block with 0.5mL/kg of 0.2% ropivacaine and Group C (n = 56) received caudal block with 1mL/kg of 0.2% ropivacaine. " 04/01/2023 - "Single paravertebral block at T11 level with 20 mL of ropivacaine (0.5%) may be an effective intraoperative anaesthetic technique in older adults with severe cardiac decompensation undergoing complex open inguinal hernia repair. " 02/01/2023 - "Forty adult patients with American Society of Anesthesiologists physical status I and II, undergoing inguinal hernia repair were randomized to receive either QL or TAP block, with 20 mL of 0.25% ropivacaine bilaterally. " 03/01/2019 - "Sixty patients undergoing inguinal hernia repair were allocated to TAP block with either ropivacaine 0.75% 20 mL or placebo 20 mL. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Bupivacaine (Bupivacaine Hydrochloride)
3.	Dexmedetomidine
4.	Lidocaine (Xylocaine)
5.	Opioid Analgesics (Opioids)
6.	Morphine (MS Contin)
7.	Fentanyl (Sublimaze)
8.	Local Anesthetics
9.	Levobupivacaine (Chirocaine)
10.	Sufentanil (Sufenta)

Related Therapies and Procedures

1.	Analgesia
2.	Catheters
3.	Anesthesia
4.	Epidural Analgesia
5.	Thoracotomy