Abstract | BACKGROUND: METHODS: Adult male Sprague-Dawley rats were anaesthetized and randomly allocated into four groups (n = 8): Groups S, R, RD1, and RD5 were injected with saline, 0.5% ropivacaine, 0.5% ropivacaine combined with 1 μg dexmedetomidine, and 0.5% ropivacaine combined with 5 μg dexmedetomidine, respectively, around the saphenous nerve. Then, the rats were subjected to skin/muscle incision and retraction (SMIR) surgery in the medial thigh. Mechanical and heat sensitivity was evaluated and morphology of the dorsal root ganglion (DRG) neurons was observed by electron microscopy. RESULTS: Some 62.5%, 50%, 12.5%, and 25% of rats developed mechanical hypersensitivity in Groups S, R, RD1, and RD5, respectively. The number of swollen mitochondria in DRG neurons was significantly more in Group S (257.2 ± 60.9) and Group R (291.6 ± 82.1) than in Group RD1 (97.2 ± 33.3) and Group RD5 (13.6 ± 17.9). In addition, the edema in endoplasmic reticulum and Golgi apparatus was decreased in Group RD1 and Group RD5 compared with Group S and Group R. CONCLUSION:
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Authors | Xizhao Huang, Rongfang Deng, Weifeng Tu, Zurong Hu |
Journal | Asian journal of surgery
(Asian J Surg)
Vol. 40
Issue 1
Pg. 35-40
(Jan 2017)
ISSN: 0219-3108 [Electronic] China |
PMID | 27131956
(Publication Type: Journal Article)
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Copyright | Copyright © 2016. Published by Elsevier Taiwan. |
Chemical References |
- Amides
- Analgesics, Non-Narcotic
- Anesthetics, Local
- Dexmedetomidine
- Ropivacaine
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Topics |
- Amides
(therapeutic use)
- Analgesics, Non-Narcotic
(therapeutic use)
- Anesthetics, Local
(therapeutic use)
- Animals
- Dermatologic Surgical Procedures
- Dexmedetomidine
(therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Injections
- Male
- Muscle, Skeletal
(surgery)
- Neuralgia
(diagnosis, etiology, prevention & control)
- Pain Measurement
- Pain, Postoperative
(diagnosis, prevention & control)
- Preoperative Care
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Ropivacaine
- Thigh
- Treatment Outcome
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