Abstract | BACKGROUND: METHODS: A tertiary care hospital-based prospective study was conducted among adult cohort with mono- infection P. vivax malaria as per the World Health Organization's protocol of in vivo assessment of anti-malarial therapeutic efficacy. Participants were treated with CQ 25 mg/kg body weight divided over 3 days and PQ 0.25 mg/kg body weight daily for 2 weeks. RESULTS: Of a total of 125 participants recruited, 122 (97.6%) completed day 28 follow up, three (2.4%) participants were lost to follow-up. Eight patients (6.4%) were ascertained to have mixed P. vivax and Plasmodium falciparum infection by nested polymerase chain reaction test. The majority of subjects (56.8%, 71/125) became aparasitaemic on day 2 followed by 35.2% (44/125) on day 3, and 8% (10/125) on day 7, and remained so thereafter. Overall only one therapeutic failure (0.8%, 1/125) occurred on day 3 due to persistence of fever and parasitaemia. CONCLUSIONS: CQ-PQ combined regimen remains outstandingly effective for uncomplicated P. vivax malaria and should be retained as treatment of choice in the study region. One case of treatment failure indicates possible resistance which warrants constant vigilance and periodic surveillance.
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Authors | Kumar Rishikesh, Asha Kamath, Manjunatha H Hande, Sudha Vidyasagar, Raviraja V Acharya, Vasudeva Acharya, Jayaprakash Belle, Ananthakrishna B Shastry, Kavitha Saravu |
Journal | Malaria journal
(Malar J)
Vol. 14
Pg. 310
(Aug 11 2015)
ISSN: 1475-2875 [Electronic] England |
PMID | 26259839
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Chloroquine
- Primaquine
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Topics |
- Adolescent
- Adult
- Aged
- Antimalarials
(administration & dosage, therapeutic use)
- Chloroquine
(administration & dosage, therapeutic use)
- Coinfection
- Drug Therapy, Combination
- Female
- Humans
- India
(epidemiology)
- Malaria, Falciparum
- Malaria, Vivax
(drug therapy, epidemiology, parasitology)
- Male
- Middle Aged
- Plasmodium falciparum
- Plasmodium vivax
(genetics)
- Polymerase Chain Reaction
- Primaquine
(administration & dosage, therapeutic use)
- Prospective Studies
- Tertiary Healthcare
- Treatment Failure
- Young Adult
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