Abstract | BACKGROUND: METHODS: Wild-type and RenTag mice were injected weekly with a supratherapeutic dose of intravenous gadodiamide (3.0 mmol/kg body weight) and killed at 12 weeks of age for skin and kidney histology. RESULTS: RenTag mice had elevated BUN levels, pitted kidneys, and glomerular damage. RenTag mice skin revealed an increased density of fibroblasts, no mucopolysaccharide deposits, and increased collagen fibril density regardless of Gd exposure. Skin and kidney histopathology of wild-type mice were normal regardless of Gd exposure. CD34 positivity was higher in RenTag compared to wild-type. CONCLUSIONS: Since RenTag dermal lesions remained unchanged after gadolinium exposure in the setting of renal failure, this animal model suggests perturbations of subcutaneous RAS may be involved in Gd-naïve dermal fibrosis.
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Authors | Sandra Sexton, Ryan Tulowitzki, Craig A Jones, Silvi Shah, George Hajduczok, Kenneth W Gross, Mandip Panesar |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 20
Issue 2
Pg. 162-8
(Apr 2016)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 26138357
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Animals
- Disease Models, Animal
- Kidney
(pathology)
- Mice, Transgenic
- Nephrogenic Fibrosing Dermopathy
(pathology)
- Renin-Angiotensin System
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