Immunotoxicity effects of carbaryl in vivo and in vitro.

Abstract

Carbaryl is a pesticide for controlling pests in agricultural industry. To determine of immunotoxicity effects of carbaryl, rats were exposure with carbaryl for 28 days. The lymphoid organ weight, lymphocyte proliferation, IL-2, IFN-γ, IL-4, IL-10, IL-1β and TNF-α cytokines level were measured, respectively. Exposure with carbaryl significantly reduced both thymus and spleen weight and also suppressed lymphocyte proliferation. In addition, carbaryl significantly decreased IL-2, IFN-γ, IL-1β and TNF-α and also increased IL-4, IL-10 cytokines. These findings suggest that exposure to carbaryl can induce immunotoxicity effects on lymphoid organ weight, suppresses the functions of lymphocyte and macrophage, Th2 polarization in Th1/Th2 balance by reducing of IFN-γ and increasing of IL-4 and IL-10 cytokines. Therefore, carbaryl can contribute to the development of allergic, autoimmune, cancer or infection diseases through immunotoxicity effects and unbalancing of Th1/Th2 immune response however, further study is necessary.

• Authors: Seyed Gholam Ali Jorsaraei, Ghorban Maliji, Abbas Azadmehr, Ali Akbar Moghadamnia, Ali Akbar Faraji
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 38 Issue 3 Pg. 838-44 (Nov 2014) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 25461543 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Cytokines
• Insecticides
• Carbaryl

Topics

• Animals
• Carbaryl (toxicity)
• Cell Culture Techniques
• Cell Proliferation (drug effects)
• Cytokines (metabolism)
• Insecticides (toxicity)
• Lymphocytes (cytology, drug effects, immunology)
• Macrophages, Peritoneal (drug effects, immunology)
• Male
• Organ Size (drug effects)
• Rats
• Spleen (immunology)
• Thymus Gland (immunology)