[Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection].

Abstract

OBJECTIVE:

To investigate the association of single nucleotide polymorphisms in the HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection.

METHODS:

Two hundred and four healthy subjects, 255 clearance subjects, 204 asymptomatic HBV carriers (AsC), 136 chronic hepatitis B (CHB), 68 liver cirrhosis (LC) and hepatocellular carcinoma (HCC) were enrolled. Genotypes of rs3077, rs9277535 and rs2647050 were determined by sequence specific primers-PCR (PCR-SSP).

RESULTS:

By using healthy subjects and clearance subjects as the control groups, rs3077 and rs9277535 were significantly associated with chronic HBV infection under additive and dominant models (P< 0.05). Meanwhile, haplotypes GGA, AGA, AAA appeared to be protective factors against chronic HBV infection (P < 0.05). By using AsC as the control group, comparison with the CHB, LC and HCC groups showed no association of the 3 SNPs or haplotypes with the clinical outcome (P > 0.05).

CONCLUSION:

HLA-DP gene polymorphisms are strongly associated with chronic HBV infection. The presence of A allele at rs3077 and rs9277535 of the HLA-DP gene may decreased the risk for chronic HBV infection.

• Authors: Mingkuan Su, Yongbin Zeng, Jing Chen, Ling Jiang, Tianbin Chen, Can Liu, Bin Yang, Qishui Ou
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 31 Issue 6 Pg. 765-9 (Dec 2014) ISSN: 1003-9406 [Print] China
• PMID: 25449085 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DP Antigens
• HLA-DQ Antigens

Topics

• Adult
• Asian People (ethnology, genetics)
• Case-Control Studies
• China (ethnology)
• Female
• Genotype
• HLA-DP Antigens (genetics)
• HLA-DQ Antigens (genetics)
• Hepatitis B virus (physiology)
• Hepatitis B, Chronic (ethnology, genetics, virology)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide