Nitrite treatment rescues cardiac dysfunction in aged mice treated with conjugated linoleic acid.

Abstract

Conjugated linoleic acid (cLA) is a commercially available weight-loss supplement that is not currently regulated by the U.S. FDA. Numerous studies suggest that cLA mediates protection against diseases including cancer, diabetes, atherosclerosis, immune function, and obesity. Based upon these reports, it was hypothesized that supplementation with cLA would improve heart function in aged wild-type (WT) mice. At 10 months of age, mice were treated with cLA, nitrite, or the combination of the two. Echocardiograms revealed that cardiac function was decreased in aged compared to young WT mice, as determined by percentage of fractional shortening. Also, contrary to the hypothesis, mice that received cLA (6-week treatment) had significantly worse cardiac function compared to controls. This effect was attenuated when mice were cotreated with cLA and nitrite. Taken together, these results suggest that cLA-mediated cardiac injury can be circumvented by nitrite supplementation in a murine model of aging.

• Authors: Kellianne M Piell, Natia Qipshidze Kelm, Megan P Caroway, Masarath Aman, Marsha P Cole
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 72 Pg. 66-75 (Jul 2014) ISSN: 1873-4596 [Electronic] United States
• PMID: 24721151 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Linoleic Acids, Conjugated
• Nitrates

Topics

• Aging
• Animals
• Blotting, Western
• Cattle
• Endothelial Cells (drug effects)
• Humans
• Linoleic Acids, Conjugated (pharmacology)
• Mice
• Mice, Inbred C57BL
• Nitrates (pharmacology)
• Ventricular Function, Left (drug effects)