Abstract | INTRODUCTION: MATERIALS AND METHODS: Consecutive patients were interviewed on comorbidities and medications. An unselected total cohort (n = 534) and a control cohort (n = 177) were analysed. A urine sample (10 ml) was collected and snap frozen before levels of uF1 + 2 were measured with an ELISA kit. Visualisation of DVT was done with compression ultrasound, supplied with venography when feasible. All patients were followed up for 3-6 months. RESULTS: DVT was diagnosed in 108/534 patients. Statistical significant higher uF1 + 2 levels were found in patients with DVT (p < 0.001), in DVT positive patients with ongoing malignancy (p = 0.034) and in pregnant women compared to the control cohort (p < 0.001). Non-significant increased urine concentrations were found in DVT positive vs. DVT negative patients with infections and traumas. CONCLUSIONS: Levels of uF1 + 2 was associated with DVT both in the total cohort and in the control cohort as well as in most patients with coexisting conditions.
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Authors | Fredrik Wexels, Anniken Haslund, Ola E Dahl, Are H Pripp, Tor E Gudmundsen, Ferencz Laszlo, Ingebjørg Seljeflot, Lars C Borris, Michael R Lassen |
Journal | Thrombosis research
(Thromb Res)
Vol. 131
Issue 6
Pg. 560-3
(Jun 2013)
ISSN: 1879-2472 [Electronic] United States |
PMID | 23680105
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Peptide Fragments
- prothrombin fragment 1.2
- Prothrombin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Peptide Fragments
(urine)
- Pregnancy
- Prothrombin
(urine)
- Ultrasonography
- Veins
(diagnostic imaging)
- Venous Thrombosis
(diagnosis, diagnostic imaging, urine)
- Young Adult
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