Biochemical risk factors for stone formation in healthy school children.

Abstract

Prevalence of urolithiasis in childhood is increasing. The wide geographic variation in the incidence of lithiasis in childhood is related to climatic, dietary, and socioeconomic factors. Many children with stone disease have a metabolic abnormality. In Southeast Asia, urinary calculi are endemic and are related to dietary factors. The main aim of this study was to determine the prevalence of renal stone, urine metabolic abnormality, control of blood pressure and demographic character in elementary school children of Qom. A cross sectional study was performed on 110 primary school children (56 girls and 54 boys) aged 7 to 11 years old. Demographic data such as age, height, weight were gathered, and systolic and diastolic blood pressure, Urine analysis and culture, urinary levels of calcium, creatinine, phosphorus, magnesium, sodium, potassium, uric acid, cystine, citrate, oxalate, protein and sonographic findings were evaluated. The mean (±SD) of age was 8.85±1.51 years. Only one child had renal stone (1%), but the prevalence of abnormal renal sonography was 7%. The most prevalent urine metabolic abnormalities were hypercalciuria (23%) and hypocitraturia (100%). 11.2% of children had positive urine culture that all were female. The prevalence of high blood pressure was 7.1% for girls and 11.1% for boys. The prevalence of renal stone in children in this study was 1%, which means the accurate judgment about the prevalence of renal stone in Qom city needs more comprehensive studies. Similar to other studies in Iran this study shows that the prevalence of hypercalciuria is significantly higher comparing to other countries, it may be associated with excessive intake of sodium.

• Authors: Mohsen Akhavan-Sepahi, Mostafa Sharifian, Maasumeh Mohkam, Mahdi Vafadar, Shamsaddin Hejazi
• Journal: Acta medica Iranica (Acta Med Iran) Vol. 50 Issue 12 Pg. 814-8 ( 2012) ISSN: 1735-9694 [Electronic] Iran
• PMID: 23456523 (Publication Type: Journal Article)
• Copyright: © 2012 Tehran University of Medical Sciences. All rights reserved.

Chemical References

• Biomarkers
• Citrates
• Sodium, Dietary

Topics

• Age Factors
• Biomarkers (urine)
• Blood Pressure
• Child
• Citrates (urine)
• Cross-Sectional Studies
• Female
• Humans
• Hypercalciuria (epidemiology, urine)
• Hypertension (epidemiology, physiopathology)
• Iran (epidemiology)
• Male
• Odds Ratio
• Prevalence
• Risk Assessment
• Risk Factors
• Sodium, Dietary (urine)
• Ultrasonography
• Urinalysis
• Urolithiasis (diagnostic imaging, epidemiology, urine)