High serum immunoglobulin G4-related retrosternal fibrosclerosis.

Abstract

A 65-year-old man with a history of exposure to asbestos complained of left leg edema. Computed tomography showed a flat, symmetrical, and longitudinal retrosternal thickening in addition to a presacral tumor. Retroperitoneal fibrosis was suspected. Serum immunoglobulin G4 (IgG4) levels were elevated (213 mg/dL). Thoracoscopic biopsy was performed. Histopathologic findings showed fibrotic tissue accompanied by proliferation of IgG4-positive plasma cells (proportion of IgG4/IgG-positive plasma cells ≥70%) indicative of multifocal fibrosclerosis.

• Authors: Kazunori Kamiya, Akira Yoshizu, Tomonori Nakazato, Hiroyuki Hayashi, Naoya Hida, Hiroaki Okamoto
• Journal: Journal of thoracic imaging (J Thorac Imaging) Vol. 27 Issue 6 Pg. W190-2 (Nov 2012) ISSN: 1536-0237 [Electronic] United States
• PMID: 22314585 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G

Topics

• Aged
• Biopsy
• Follow-Up Studies
• Humans
• Immunoglobulin G (blood)
• Male
• Retroperitoneal Fibrosis (blood, congenital, diagnostic imaging, pathology)
• Sclerosis
• Sternum (diagnostic imaging)
• Tomography, X-Ray Computed (methods)