Abstract | OBJECTIVES:
Octreotide is a somatostatin analog, long-acting formulations of which have been used experimentally for the treatment of patients with invasive tumors and/or residual disease after conventional therapies. The objective of this retrospective study was to evaluate the efficacy of long-acting octreotide ( Sandostatin LAR) for the treatment of thymic tumors, with a primary efficacy end point of progression-free survival. METHODS: RESULTS: Treatment with long-acting octreotide gave the following results: 3 cases of partial response (25%), 5 cases of stable disease (42%), and 4 cases of progressive disease (33%), with an average progression-free survival of 8 months (range, 3 to 21). Treatment compliance and tolerability were good for all evaluated patients. CONCLUSIONS:
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Authors | Flavia Longo, Lucilla De Filippis, Andrea Zivi, Domenico Vitolo, Ester Del Signore, Bruno Gori, Daniele Diso, Marco Anile, Federico Venuta, Tiziano De Giacomo, Camillo Furio Coloni |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 35
Issue 2
Pg. 105-9
(Apr 2012)
ISSN: 1537-453X [Electronic] United States |
PMID | 21325939
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Delayed-Action Preparations
- Indium Radioisotopes
- Somatostatin
- pentetreotide
- Octreotide
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Topics |
- Adult
- Aged
- Antineoplastic Agents, Hormonal
(administration & dosage, adverse effects, therapeutic use)
- Carcinoma
(drug therapy)
- Delayed-Action Preparations
- Disease-Free Survival
- Drug Administration Schedule
- Female
- Humans
- Indium Radioisotopes
- Injections, Intramuscular
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(diagnostic imaging, drug therapy, mortality)
- Neoplasm, Residual
(drug therapy)
- Octreotide
(administration & dosage, adverse effects, therapeutic use)
- Pilot Projects
- Positron-Emission Tomography
- Research Design
- Retrospective Studies
- Sample Size
- Somatostatin
(analogs & derivatives)
- Thymus Neoplasms
(diagnostic imaging, drug therapy, mortality)
- Tomography, X-Ray Computed
- Treatment Outcome
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