Splenic infarction associated with sorafenib use in a hepatocellular carcinoma patient.

Abstract

Sorafenib, a multitargeted tyrosine kinase inhibitor, has been shown to improve survival in patients with advanced hepatocellular carcinoma (HCC). As the clinical use of sorafenib increases, many adverse effects have been reported, such as hand-foot skin reaction, diarrhea, anorexia, asthenia, alopecia, weight loss, hypertension and arterial thromboembolism. However, there are no prior reports of splenic infarction as an adverse effect of sorafenib. Here, a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib. The splenic infarction improved after sorafenib was discontinued; however, the HCC progressed.

• Authors: Sang Ock Kim, Sang Young Han, Yang Hyun Baek, Sung Wook Lee, Ji Sun Han, Byung Geun Kim, Jin Han Cho, Kyung Jin Nam
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 17 Issue 2 Pg. 267-70 (Jan 14 2011) ISSN: 2219-2840 [Electronic] United States
• PMID: 21246003 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzenesulfonates
• Contrast Media
• Phenylurea Compounds
• Protein Kinase Inhibitors
• Pyridines
• Niacinamide
• Sorafenib
• Aspirin

Topics

• Aged
• Antineoplastic Agents (adverse effects)
• Aspirin (administration & dosage)
• Benzenesulfonates (adverse effects)
• Carcinoma, Hepatocellular (drug therapy)
• Contrast Media (pharmacology)
• Female
• Humans
• Liver Neoplasms (drug therapy)
• Niacinamide (analogs & derivatives)
• Phenylurea Compounds
• Protein Kinase Inhibitors (adverse effects)
• Pyridines (adverse effects)
• Sorafenib
• Spleen (pathology)
• Splenic Infarction (chemically induced)
• Tomography, X-Ray Computed (methods)
• Treatment Outcome