Abstract | BACKGROUND: Some patients experience cognitive disturbances with topiramate. CASE HISTORIES: RESULTS: Within days of starting topiramate, the women began to exhibit troublesome word- and phrase-repetition and word substitution, both occurring only in their written expression. The symptoms were associated with mild sedation, persisted during two weeks of topiramate treatment, and remitted days after topiramate was withdrawn. DISCUSSION: The presence of the learning disorders and the sensitivity to the sedative adverse effects of drugs may explain why cognitive adverse effects, known to occur with topiramate, developed at the low dose of 25-50 mg/day. The proclivity of topiramate to affect language functions and a possible familial vulnerability herein may explain why the women explained similar, language-specific symptoms. An investigation of topiramate-induced cognitive impairments in family members with epilepsy may throw light on the subject.
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Authors | Chittaranjan Andrade, Savita G Bhakta, Praveen P Fernandes |
Journal | Indian journal of psychiatry
(Indian J Psychiatry)
Vol. 52
Issue 3
Pg. 260-3
(Jul 2010)
ISSN: 1998-3794 [Electronic] India |
PMID | 21180413
(Publication Type: Journal Article)
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