Abstract | BACKGROUND: METHODS: In a prospective study of the general population (n=10 392) with 60 years of follow-up, the Copenhagen City Heart Study, we associated two variants of CYP2C9 ( CYP2C9*2 and CYP2C9*3) with risk of tobacco-related cancer and all cancer. All results were re-tested in a cross-sectional study of the general population (n=36 856), the Copenhagen General Population Study. RESULTS: We found no association between any of the CYP2C9 genotypes and risk of tobacco-related cancer, individual tobacco-related cancers, or all cancer. For the combined carriers (any CYP2C9*2 or CYP2C9*3 heterozygotes or homozygotes) vs. non-carriers we had 90% statistical power to exclude measures of relative risks below/above 0.8/1.2 and 0.9/1.1 in the Copenhagen City Heart Study and below/above 0.8/1.3 and 0.9/1.1 in the Copenhagen General Population Study for tobacco-related cancer and all cancer, respectively. CONCLUSION: Genetic variations in CYP2C9 do not affect risk of tobacco-related cancers.
|
Authors | Diljit Kaur-Knudsen, Børge Grønne Nordestgaard, Stig Egil Bojesen |
Journal | Cancer epidemiology
(Cancer Epidemiol)
Vol. 34
Issue 2
Pg. 178-83
(Apr 2010)
ISSN: 1877-783X [Electronic] Netherlands |
PMID | 20117066
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- CYP2C9 protein, human
- Cytochrome P-450 CYP2C9
- Aryl Hydrocarbon Hydroxylases
|
Topics |
- Adult
- Aged
- Aryl Hydrocarbon Hydroxylases
(genetics, metabolism)
- Cocarcinogenesis
- Cohort Studies
- Cytochrome P-450 CYP2C9
- Denmark
(epidemiology)
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Neoplasms
(enzymology, epidemiology, genetics)
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Prospective Studies
- Smoking
(adverse effects, epidemiology, genetics, metabolism)
|