Malignant peripheral nerve sheath tumor of the uterine cervix expressing both S-100 protein and HMB-45.

Abstract

A 50-year-old woman presented with a large cervical polypoid mass. Grossly, the mass occupied a substantial proportion of the cervical canal, measuring 6 cm. Histologically, the mass showed a spindle cell malignancy arranged in large fascicles that penetrated deeply into the fibromuscular wall of the cervix. The spindle cells were immunoreactive for both S-100 protein and HMB-45 antigen, but were negative for Melan-A. Electron microscopy showed that cytoplasmic processes of the spindle to oval tumor cells contained microtubules and were lined by basal lamina and abundant intercellular collagen spacing with no melanosomes in any stage. As far as we are aware, this is the ninth reported case of cervical malignant peripheral nerve sheath tumor (MPNST), and the second reported case of MPNST expressing HMB-45 antigen.

• Authors: Na Rae Kim, Dong-Hae Chung, Chan Yong Park, Seung Yeon Ha
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 35 Issue 6 Pg. 1136-41 (Dec 2009) ISSN: 1447-0756 [Electronic] Australia
• PMID: 20025639 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Neoplasm
• Melanoma-Specific Antigens
• Neoplasm Proteins
• S100 Proteins

Topics

• Antigens, Neoplasm (biosynthesis)
• Female
• Humans
• Melanoma-Specific Antigens
• Middle Aged
• Neoplasm Proteins (biosynthesis)
• Nerve Sheath Neoplasms (drug therapy, metabolism, secondary, surgery, ultrastructure)
• Peritoneal Neoplasms (drug therapy, metabolism, secondary)
• S100 Proteins (biosynthesis)
• Uterine Cervical Neoplasms (metabolism, surgery)