Calix[4]arene decorated with four Tn antigen glycomimetic units and P3CS immunoadjuvant: synthesis, characterization, and anticancer immunological evaluation.

Abstract	A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized. Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix[4]arene scaffold bearing an immunoadjuvant moiety (P3CS). The immunogenicity of the synthetic construct has been investigated by immunization of mice in vivo. ELISA assay has evidenced that the tetravalent construct stimulates a higher production of anti-Tn antigen IgG antibodies when compared to an analogous monovalent compound. This result is ascribable to an antigen cluster effect and makes the reported vaccine candidate a good mimic of the natural motifs present on the mucine surface.
Authors	Corrada Geraci, Grazia M L Consoli, Eva Galante, Ennio Bousquet, Maria Pappalardo, Angelo Spadaro
Journal	Bioconjugate chemistry (Bioconjug Chem) Vol. 19 Issue 3 Pg. 751-8 (Mar 2008) ISSN: 1043-1802 [Print] United States
PMID	18293897 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Antibodies, Neoplasm Antigens, Tumor-Associated, Carbohydrate Cancer Vaccines Dipeptides Immunoglobulin G Indicators and Reagents Lipoproteins Phenols Tn antigen calix(4)arene Calixarenes 2,3-bis-(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinylserine
Topics	Adjuvants, Immunologic (chemistry) Animals Antibodies, Neoplasm (biosynthesis, immunology) Antigens, Tumor-Associated, Carbohydrate (chemistry, immunology) Calixarenes (chemistry, immunology) Cancer Vaccines (chemistry, immunology) Chromatography, Thin Layer Dipeptides (chemistry, immunology) Enzyme-Linked Immunosorbent Assay Female Immunoglobulin G (biosynthesis, immunology) Immunotherapy (methods) Indicators and Reagents Lipoproteins (chemistry, immunology) Magnetic Resonance Spectroscopy Mice Mice, Inbred BALB C Molecular Mimicry Neoplasms (immunology, prevention & control) Phenols (chemistry, immunology) Spectrometry, Mass, Electrospray Ionization

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